Surface antigen expression of human neoplastic plasma cells includes molecules associated with lymphocyte recirculation and adhesion
| Autor: | M. S. Hamilton, J. Ball, I. M. Franklin, E. Bromidge |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Lymphocyte
Plasma Cells chemical and pharmacologic phenomena Biology Epitope CD19 Leukemia Plasma Cell Antigen Antigens Neoplasm hemic and lymphatic diseases Plasma cell differentiation Tumor Cells Cultured medicine Humans Lymphocytes Pan-T antigens B cell MHC class II Hematology Molecular biology Antigens Differentiation B-Lymphocyte medicine.anatomical_structure Antigens Surface Immunology biology.protein Multiple Myeloma Cell Adhesion Molecules |
| Zdroj: | British Journal of Haematology. 78:60-65 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1991.tb04383.x |
| Popis: | Summary The surface phenotype of neoplastic plasma cells from peripheral blood of plasma cell leukaemia patients and bone marrow of patients with myelomatosis was investigated with two monoclonal antibody panels including 50 selected from the B cell panel of the IVth International Workshop on Leucocyte Differentiation Antigens. The majority of myelomas expressed CD24 (HB8 epitope only), CD38, CD44, CD54, and the antigen recognized by the monoclonal antibody 8A. A range of other antigens may also be expressed including CD10, CD32 (FcR II), CD19, CD20 and MHC Class II. Antigens expressed by myeloma plasma cells can be considered in three groups: (a) antigens associated with lymphocyte and plasma cell differentiation: (b) antigens which are not lineage specific: and (c) molecules concerned with lymphocyte recirculation and intercellular adhesion (CD44 and CD54). The significance of CD44 and CD54 expression by plasma cells and the potential interaction of plasma cells with T lymphocytes and monocytes is discussed. |
| Databáze: | OpenAIRE |
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