Altered visual functions, macular ganglion cell and papillary retinal nerve fiber layer thickness in early-treated adult PKU patients

Autor: Endre Horvath, Csaba Sumanszki, Csilla Serfozo, Béla Csákány, András Gellért Barta, Péter Reismann, Miklós D. Resch, Zoltán Zsolt Nagy
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Intraocular pressure
genetic structures
Dopamine
FLV
focal loss of volume
Nerve fiber layer
ETPKU
early-treated phenylketonuria
PD
Parkinson's disease
OCTA
optical coherence tomography angiography
chemistry.chemical_compound
Endocrinology
ETDRS
early treatment diabetic retinopathy study
VEPs
Visual evoked potentials
Myopia
Contrast (vision)
Phenylketonuria
lcsh:QH301-705.5
media_common
lcsh:R5-920
OCT
optical coherence tomography
medicine.diagnostic_test
Phenylalanine level
GCC
ganglion cell layer thickness
LogMAR
logarithm of the minimum angle of resolution
Ganglion
Stereoscopic acuity
VD
vessel density
medicine.anatomical_structure
SD
spectral domain
AL
axial length
D
diopters
Phe
phenylalanine
lcsh:Medicine (General)
Research Paper
BCVA
best corrected visual acuity
medicine.medical_specialty
media_common.quotation_subject
PKU
phenylketonuria
GMP
Glycomacropeptide
SE
spherical equivalent
Retinal nerve fiber layer thickness
Ophthalmology
Genetics
medicine
AAS
aminoacid supplements
SWCT
sine wave contrast test
RNFL
retinal nerve fiber layer
Ganglion cell layer thickness
Molecular Biology
Ganglion cell layer
business.industry
BH4
Tetrahydrobiopterine
Retinal
RNFLT
retinal nerve fiber layer thickness
IOP
intraocular pressure
eye diseases
Optical coherence tomography angiography
chemistry
lcsh:Biology (General)
Angiography
GLV
global loss of volume
DA
dopamine
sense organs
business
Zdroj: Molecular Genetics and Metabolism Reports, Vol 25, Iss, Pp 100649-(2020)
Molecular Genetics and Metabolism Reports
ISSN: 2214-4269
Popis: Purpose: Retinal changes are poorly described in early treated phenylketonuria (ETPKU). We aimed to investigate possible visual functional and ocular microstructural changes in adult patients with ETPKU. Optical coherence tomography (OCT) and its angiography (OCTA) data from patients with PKU were compared to healthy controls. Methods: In this prospective, monocentric, cross-sectional, case-control study 50 patients with ETPKU and 50 healthy subjects were evaluated with OCT and OCTA. Measurements were performed on right eyes. The following visual function parameters were studied: best corrected visual acuity (BCVA), spherical equivalent (SE), contrast sensitivity and near stereoacuity; microstructural parameters: retinal nerve fiber layer thickness (RNFLT), ganglion cell layer (GCC) thickness, focal loss of volume (FLV), global loss of volume (GLV), peripapillary, papillary vessel density (VD), ocular axial length (AL) and intraocular pressure (IOP). Results: Among functional tests there were significant differences in contrast sensitivity at 1.5 (p
Databáze: OpenAIRE
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