Hodgkin's lymphoma and infection: findings from a UK case–control study
| Autor: | Robert U. Newton, J. Simpson, Andrew Jack, Eve Roman, C. Burton, Simon Crouch, Alison Smith, Eleanor V. Willett, Pat Ansell |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Epidemiology Population lymphoma Infections Communicable Diseases Medical Records Risk Factors Internal medicine medicine Humans education Aged education.field_of_study business.industry Medical record Case-control study Cancer Middle Aged Hodgkin's lymphoma medicine.disease Hodgkin Disease infection Confidence interval Surgery Lymphoma England Oncology Case-Control Studies Hodgkin's Female Abnormality business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Between 1998 and 2003, 214 people with Hodgkin's lymphoma and 214 controls randomly selected from population registers in the north of England (after matching for age and sex) were recruited and their primary care medical records examined for details of clinical diagnoses due to infectious and non-infectious conditions in the preceding 15 years. In the year before diagnosis of Hodgkin's lymphoma, almost all cases (99%) visited their general practitioner (GP) at least once. In comparison with controls, the excess was evident both for visits with an infection (odd's ratio (OR)=2.1; 95% confidence interval (CI) 1.4–3.2) and for visits with non-infectious problems (OR=17.2; 95% CI 6.7–43.9). During the rest of the 15-year period prior to diagnosis, the proportion of people visiting their GP with a non-infectious condition did not differ between cases and controls. In contrast, compared to controls, there was an excess of cases visiting the GP with an infection, a finding that was evident for at least a decade prior to diagnosis and increased linearly with time (P=0.02). This excess was not due to a specific infection(s) and may reflect underlying immune abnormality. Alternatively, infection may cause B-cell proliferation from which a malignant clone may evolve. |
| Databáze: | OpenAIRE |
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