Evaluation of the hepatoprotective effect of Yigan mingmu oral liquid against acute alcohol-induced liver injury in rats
| Autor: | Bingxin Ma, Xie Baibo, Yuxin Chen, Linyou Cheng, Qigui Mo, James Hua Zhou, Gao Zhou, Youwei Wang, Zang Xinyu |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Alcoholic liver disease Alcohol 030204 cardiovascular system & hematology Pharmacology medicine.disease_cause Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipid droplet medicine Oil Red O Animals Transaminases Liver injury Plants Medicinal business.industry lcsh:Other systems of medicine Glutathione lcsh:RZ201-999 medicine.disease Hepatoprotective Yigan mingmu oral liquid Staining Rats Disease Models Animal Complementary and alternative medicine chemistry Liver Oxidative stress Chemical and Drug Induced Liver Injury business 030217 neurology & neurosurgery Drugs Chinese Herbal Research Article |
| Zdroj: | BMC Complementary Medicine and Therapies BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2662-7671 |
| Popis: | Background Yigan mingmu oral liquid (YGMM) is a herbal medicine based on a famous Chinese herbal formula that has been used for sore eyes for more than 400 years. Eye health is closely associated with the liver based on TCM. This study aimed to investigate the hepatoprotective effect of YGMM against acute liver injury induced by alcohol in rats. Methods Experimental rats were administered with silymarin and YGMM through the gastric gavage during the entire experiment. Starting from the 11th day, the rats were administered orally with 14 ml/kg Red Star Erguotou Liquor, a popular brand, at 4 h after the dose of silymarin (100 mg/kg) and YGMM (1, 2.5 and 5 ml/kg in low, middle and high dosage group, respectively) once a day for 4 weeks except for the rats in the normal group. Biochemical parameters, including ALT, AST, TB, TG, T-SOD, GSH, and MDA were detected to evaluate the protective effect of YGMM. Pathological changes were observed through histopathological examination. Results Treatment with YGMM exhibited a significant protective effect by reversing the biochemical parameters (ALT, AST, TB, TG, and GSH) and histopathological changes. Histopathological examination by Oil Red O Staining Solution showed that lipid droplets were significantly reduced in the silymarin and YGMM groups (p Conclusions YGMM exhibits a significant hepatoprotective activity against acute liver injury induced by alcohol in rats. |
| Databáze: | OpenAIRE |
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