A comparison of the antiserotonin, antihistamine, and anticholinergic activity of cyproheptadine with analogs having furan nuclei fused to the 10,11-vinylene bridge
| Autor: | Remy David C, Edward L. Engelhardt, Kenneth E. Rittle, Victor J. Lotti, A. Scriabine, Andrew W. Raab |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Stereochemistry medicine.drug_class medicine.medical_treatment Guinea Pigs Cyproheptadine Bronchi Mice chemistry.chemical_compound Furan Drug Discovery medicine Anticholinergic Animals Edema Furans Parasympatholytics Pupil Rats chemistry Histamine H1 Antagonists Molecular Medicine Female Antihistamine Serotonin Antagonists Piperidine medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 20:836-838 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | A series of cyproheptadine derivatives having furan nuclei fused to the 10,11-vinylene bridge has been prepared. None of the compounds retain the potent antiserotonin and antihistaminic actions of cyproheptadine. 1-methyl-4-(1-methyl-8H-dibenzo[a,e]furo[3,4-c]cyclohepten-8-ylidene)piperidine (7), 1-methyl-4-(1,3-dihydro-1-oxo-8H-[3,4:6,7]cycloheptal[1,2-c]furan-8-ylidene)piperidine (10), and its reduction product 11 retained the peripheral anticholinergic activity of cyproheptadine. |
| Databáze: | OpenAIRE |
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