Altered emotion processing circuits during the anticipation of emotional stimuli in women with borderline personality disorder
| Autor: | Lutz Jäncke, Annette Beatrix Brühl, Sarah Opialla, Lilian Roth, Sigrid Scherpiet, Uwe Herwig |
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| Přispěvatelé: | University of Zurich, Scherpiet, Sigrid |
| Rok vydání: | 2013 |
| Předmět: |
Cingulate cortex
Adult medicine.medical_specialty Psychometrics Brain activity and meditation 610 Medicine & health Audiology behavioral disciplines and activities Developmental psychology Lingual gyrus 2738 Psychiatry and Mental Health 03 medical and health sciences Young Adult 0302 clinical medicine Borderline Personality Disorder DoktoratPSYCH Erstautor mental disorders medicine Image Processing Computer-Assisted 2736 Pharmacology (medical) Humans Pharmacology (medical) Affective Symptoms Biological Psychiatry Anterior cingulate cortex Brain Mapping Motivation medicine.diagnostic_test 10093 Institute of Psychology Brain General Medicine Middle Aged Emotional dysregulation Anticipation Magnetic Resonance Imaging 030227 psychiatry Dorsolateral prefrontal cortex Oxygen Psychiatry and Mental health medicine.anatomical_structure 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics Female Self Report 150 Psychology Psychology Functional magnetic resonance imaging 2803 Biological Psychiatry 030217 neurology & neurosurgery Photic Stimulation |
| Zdroj: | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE European archives of psychiatry and clinical neuroscience |
| ISSN: | 1433-8491 |
| Popis: | Borderline personality disorder (BPD) is associated with disturbed emotion processing, typically encompassing intense and fast emotional reactions toward affective stimuli. In this study, we were interested in whether emotional dysregulation in BPD occurs not only during the perception of emotional stimuli, but also during the anticipation of upcoming emotional pictures in the absence of concrete stimuli. Eighteen female patients with a diagnosis of BPD and 18 healthy control subjects anticipated cued visual stimuli with prior known emotional valence or prior unknown emotional content during functional magnetic resonance imaging. Brain activity during the anticipation of emotional stimuli was compared between both groups. When anticipating negative pictures, BPD patients demonstrated less signal change in the left dorsal anterior cingulate cortex (dACC) and left middle cingulate cortex (MCC), and enhanced activations in the left pregenual ACC, left posterior cingulate cortex (PCC) as well as in left visual cortical areas including the lingual gyrus. During the anticipation of ambiguously announced stimuli, brain activity in BPD was also reduced in the left MCC extending into the medial and bilateral dorsolateral prefrontal cortex. Results point out that deficient recruitment of brain areas related to cognitive-emotional interaction already during the anticipation phase may add to emotional dysregulation in BPD. Stronger activation of the PCC could correspond to an increased autobiographical reference in BPD. Moreover, increased preparatory visual activity during negative anticipation may contribute to hypersensitivity toward emotional cues in this disorder. |
| Databáze: | OpenAIRE |
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