Genetic diversity and clinical impact of human rhinoviruses in hospitalized and outpatient children with acute respiratory infection, Argentina

Autor:	Guadalupe Carballal, Rodolfo Hector Campos, Marcela Echavarria, Débora Natalia Marcone, Andrés Carlos Alberto Culasso
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Male Rhinovirus Ciencias de la Salud Sequence Homology law.invention law Epidemiology HRV human rhinoviruses Outpatients Cluster Analysis Children Respiratory Tract Infections Phylogeny hMPV human metapneumovirus 5′NCR 5′ non-coding region Molecular Epidemiology Reverse Transcriptase Polymerase Chain Reaction Acute Respiratory Infection Respiratory infection virus diseases ARI acute respiratory infection Intensive care unit Infectious Diseases Treatment Outcome Acute respiratory infection Child Preschool Coinfection Bronchitis RNA Viral Female Human rhinoviruses circulatory and respiratory physiology Human Rhinoviruses medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Genotype Flu influenza Genotypes Molecular Sequence Data Argentina Article LRTI lower respiratory tract infection stomatognathic system Virology Lower respiratory tract infection Internal medicine otorhinolaryngologic diseases medicine Epidemiología BSP Bayesian skyline plot Humans IF immunofluorescence Risk factor Intensive care medicine AdV adenovirus Inpatients Picornaviridae Infections business.industry Genetic Variation Infant MCC maximum clade credibility Sequence Analysis DNA PIV parainfluenza medicine.disease Enfermedades Infecciosas Cross-Sectional Studies Bronchiolitis HPD highest probability density URTI upper respiratory tract infection RSV respiratory syncytial virus business tMRCA time of the most recent common ancestor BA Buenos Aires
Zdroj:	Journal of Clinical Virology
ISSN:	1873-5967 1386-6532
Popis:	Graphical abstract Human rhinoviruses (HRV) detection during two consecutive years, in children with respiratory infection, without comorbidities, in Buenos Aires, Argentina (2008–2010). Phylogenetic analysis of HRV clusters in relation to their demographic reconstruction in a time scale. Highlights • Human rhinoviruses (HRV) were detected in 40% of children with ARI without comorbidities. • HRV were identified as a risk factor associated with hospitalization (OR: 2.47). • All HRV species co-circulated, being HRV-A and C the most frequently detected. • Demographic and clinical outcome were similar for HRV-A and C infections. • A high turnover rate of HRV genotypes was observed. Background Human rhinoviruses (HRV) are recognized as a cause of upper and lower acute respiratory infections (ARI). The circulating species and their clinical impact were not described in Argentina. Objectives To describe the molecular epidemiology of HRV in children and to determine the association of HRV species with outcome and severity. Study design: Hospitalized and outpatients children
Databáze:	OpenAIRE
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