Patient Perspective on the Value of Genetic Counselling for Familial Pancreas Cancer
Autor: | Kieran Brune, Lori Wroblewski, Jennifer E. Axilbund, Brenda C Brehon, Constance A. Griffin, Marcia I. Canto |
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Jazyk: | angličtina |
Rok vydání: | 2005 |
Předmět: |
medicine.medical_specialty
lcsh:QH426-470 Referral Genetic counseling Disease Malignancy lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine pancreas cancer medicine 030212 general & internal medicine Family history Genetics (clinical) Genetic testing Gynecology medicine.diagnostic_test business.industry Research Cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Human genetics 3. Good health lcsh:Genetics Oncology 030220 oncology & carcinogenesis Family medicine business genetic counselling |
Zdroj: | Hereditary Cancer in Clinical Practice Hereditary Cancer in Clinical Practice, Vol 3, Iss 3, Pp 115-122 (2005) |
ISSN: | 1897-4287 1731-2302 |
Popis: | Purpose To assess patient views regarding the value of genetic counselling for familial pancreas cancer in the absence of predictive genetic testing. Patients and methods At-risk adults with three or more relatives with pancreas cancer received genetic counselling prior to research screening via endoscopic ultrasound. Questionnaires were mailed after the visit to assess perceived value of the counselling session. Results Ninety-three percent of respondents felt genetic counselling for pancreas cancer was helpful despite the lack of a causative gene, while only 7% felt that it should not be offered until such a gene is discovered. Over half of respondents believed the pancreas cancer in their family was caused by a gene mutation, and 42% thought they had inherited the mutation. The average perceived lifetime risk of developing pancreas cancer was 51%, and 87% of respondents would ultimately seek predictive genetic testing. When more information is gained, 89% would be interested in another genetic counselling session, and 82% would recommend current genetic counselling for pancreas cancer to a friend or relative with a family history of the disease. Conclusion Despite the lack of an identified major causative gene for pancreas cancer, respondents found genetic counselling for this malignancy to be helpful. These patients perceive their personal cancer risk to be high, and would seek predictive genetic testing if it were available. Referral for genetic counselling should be offered to appropriate individuals. |
Databáze: | OpenAIRE |
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