Prenatal exposure to cigarette smoke and anogenital distance at 4 years in the INMA‐Asturias cohort
| Autor: | Rocío Fernández-Iglesias, Adonina Tardón, Isolina Riaño-Galán, Ana Fernández-Somoano, Izaro Babarro, Miguel García-Villarino, Cristina Rodriguez-Dehli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Offspring Health Toxicology and Mutagenesis Anal Canal Article maternal cigarette smoking 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Smoke Medicine Humans 030212 general & internal medicine anogenital distance tobacco smoking Child endocrine-disrupting chemicals 030219 obstetrics & reproductive medicine business.industry Obstetrics Anogenital distance Smoking Public Health Environmental and Occupational Health Infant Newborn medicine.disease Confidence interval Passive Smoke Exposure Low birth weight chemistry Maternal Exposure Spain Prenatal Exposure Delayed Effects Cohort Female medicine.symptom business Cotinine |
| Zdroj: | Scopus International Journal of Environmental Research and Public Health, Vol 18, Iss 4774, p 4774 (2021) RUO. Repositorio Institucional de la Universidad de Oviedo instname Addi. Archivo Digital para la Docencia y la Investigación International Journal of Environmental Research and Public Health Addi: Archivo Digital para la Docencia y la Investigación Universidad del País Vasco Volume 18 Issue 9 |
| Popis: | Smoking by women is associated with adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, low birth weight, infertility, and prolonged time to pregnancy. Anogenital distance (AGD) is a sensitive biomarker of prenatal androgen and antiandrogen exposure. We investigated the effect of smoking and passive smoke exposure during pregnancy on anogenital distance in offspring at 4 years in the INMA-Asturias cohort (Spain). Women were interviewed during pregnancy to collect information on tobacco consumption, and anogenital distance was measured in 381 children: Anoscrotal distance in boys and anofourchetal distance in girls. We also measured maternal urinary cotinine levels at 32 weeks of pregnancy. We constructed linear regression models to analyze the association between prenatal smoke exposure and anogenital distance and adjusted the models by relevant covariates. Reported prenatal smoke exposure was associated with statistically significant increased anogenital index (AGI), both at week 12 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) and at week 32 of pregnancy (β = 0.31, 95% confidence interval: 0.00, 0.63) in male children, suggesting altered androgenic signaling. Funding was provided by CIBERESP (PhD employment contract and fellowship for short stays abroad—2019), FIS-FEDER (grants PI04/2018, PI09/02311, PI13/02429, and PI18/00909), Obra Social Cajastur/Fundación Liberbank, and Universidad de Oviedo. |
| Databáze: | OpenAIRE |
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