The Prevalence of Renal Impairment in Patients with Spondyloarthritis: Results from the International ASAS-COMOSPA Study
| Autor: | Maxime Dougados, Anna Molto, Marion Couderc, Aurélien Tiple, Martin Soubrier, Bruno Pereira |
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| Přispěvatelé: | Imagerie Moléculaire et Stratégies Théranostiques - Clermont Auvergne (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Université Paris Descartes - Paris 5 (UPD5), CHU Cochin [AP-HP], Université Sorbonne Paris Cité (USPC), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Department of Clinical Research and Innovation (DRCI), CHU Clermont-Ferrand, Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], CHU Clermont-Ferrand, Service de rhumatologie [Clermont-Ferrand], CHU Clermont-Ferrand-Hôpital Gabriel Montpied, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP) |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Disease duration [SDV]Life Sciences [q-bio] Immunology Renal function [SDV.CAN]Life Sciences [q-bio]/Cancer Disease Comorbidity Kidney Kidney Function Tests Severity of Illness Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Disease severity Internal medicine Spondylarthritis medicine Prevalence Immunology and Allergy Humans In patient 030212 general & internal medicine BASDAI ComputingMilieux_MISCELLANEOUS 030203 arthritis & rheumatology Ankylosing spondylitis Nonsteroidal business.industry Anti-Inflammatory Agents Non-Steroidal Age Factors Middle Aged medicine.disease 3. Good health chemistry Female Kidney Diseases business Glomerular Filtration Rate |
| Zdroj: | Journal of Rheumatology Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2018, 45 (6), pp.795-801. ⟨10.3899/jrheum.170133⟩ Journal of Rheumatology, 2018, 45 (6), pp.795-801. ⟨10.3899/jrheum.170133⟩ |
| ISSN: | 0315-162X 1499-2752 |
| DOI: | 10.3899/jrheum.170133⟩ |
| Popis: | Objective.To assess the prevalence and association of renal dysfunction in patients with spondyloarthritis (SpA).Methods.The ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) was an international study (22 participating countries from 4 continents) investigating comorbidities in SpA. Renal function was assessed based on estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease equation. SpA characteristics and risk factors for renal impairment were collected. Nonsteroidal antiinflammatory drug (NSAID) use was assessed based on current intake (last 3 mos).Results.Of the 3984 patients recruited, 2098 (52.6%) were analyzed after excluding outliers and patients with no available eGFR measurement [male sex: 63.5%; age: 45.3 yrs; disease duration: 8.6 years; HLA-B27+: 73.1%; Bath Ankylosing Spondylitis Activity Index (BASDAI): 3.6/10]. Overall, 153 patients (5.2%, mean age: 53.6 yrs) exhibited an eGFR < 60 ml/min/1.73 m2. In univariate analysis, renal impairment was associated with age (p < 0.001), HLA-B27 positivity (p = 0.003), several cardiovascular (CV) risk factors (history of hypertension, p < 0.001; systolic blood pressure, p = 0.009; diabetes, p = 0.005; and Framingham risk score, p < 0.001), disease activity scores [BASDAI, p = 0.001; Ankylosing Spondylitis Disease Activity Score-C-reactive protein (ASDAS-CRP), p < 0.001], functional variables (Bath Ankylosing Spondylitis Functional Index, p < 0.001), inflammatory biomarkers (erythrocyte and CRP, both p < 0.001), and NSAID intake since onset of disease (percentage of days, p = 0.008). However, there was no association with disease duration, disease severity, or ASAS-NSAID score. In multivariate analysis, age (45–59 yrs: OR 1.9, > 60 yrs: OR 6.2), HLA-B27 positivity (OR 0.51), and CRP (OR 1.3) remained significantly associated with eGFR < 60 ml/min/1.73 m2.Conclusion.Renal impairment was associated with age, HLA-B27 positivity, and inflammation, though not with CV risk factors, disease severity, or NSAID intake in patients with SpA. |
| Databáze: | OpenAIRE |
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