Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)
| Autor: | Huisuk Yang, Geonwoo Kang, Jee Hye Nam, Youseong Kim, Jiwoo Shin, Hyungil Jung, Jinkyung Kim, Hye Su Min, Daniel Junmin Um, Mingyu Jang, Chisong Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Skin barrier
poly(lactic-co-glycolic acid) dissolving microneedle Pharmaceutical Science 02 engineering and technology Article 03 medical and health sciences chemistry.chemical_compound Pharmacy and materia medica drug delivery system Porcine skin sustained release Dissolution Glycolic acid 030304 developmental biology Transdermal 0303 health sciences technology industry and agriculture 021001 nanoscience & nanotechnology RS1-441 PLGA chemistry Drug delivery thermoplastic characteristics melting method 0210 nano-technology Ex vivo Biomedical engineering |
| Zdroj: | Pharmaceutics Volume 13 Issue 7 Pharmaceutics, Vol 13, Iss 1058, p 1058 (2021) |
| ISSN: | 1999-4923 |
| Popis: | Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the use of potentially harmful organic solvents. The drug-loaded PLGA mixture, which consisted of a middle layer of the DMN, was optimized and successfully implanted into ex vivo porcine skin. Implanted HMP-DMNs separated from the patch within 10 min, enhancing user compliance, and the encapsulated molecules were released for nearly 4 weeks thereafter. In conclusion, the geometry of HMP-DMNs was successfully optimized for safe and effective transdermal sustained drug delivery without the use of organic solvents. This study provides a strategy for the innovative utilization of PLGA as a material for transdermal drug delivery systems. |
| Databáze: | OpenAIRE |
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