Experience in Renal and Extrarenal Transplantation with Donation after Cardiac Death Donors with Selective Use of Extracorporeal Support
| Autor: | Michael H. Hines, Jeffrey Rogers, Rajinder Singh, Patricia L. Adams, Erica L. Hartmann, Samy S. Iskandar, Robert J. Stratta, Amber Reeves-Daniel, Michael D. Gautreaux, Alan C. Farney |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Extracorporeal Circulation medicine.medical_specialty Delayed Graft Function Renal function Expanded Criteria Donor Extracorporeal Outcome Assessment Health Care medicine Humans Kidney transplantation Aged Retrospective Studies Kidney business.industry Incidence (epidemiology) Donation after cardiac death Middle Aged medicine.disease Kidney Transplantation Tissue Donors Surgery Death Perfusion Transplantation medicine.anatomical_structure Tissue and Organ Harvesting Female Pancreas Transplantation business |
| Zdroj: | Journal of the American College of Surgeons. 206:1028-1037 |
| ISSN: | 1072-7515 |
| DOI: | 10.1016/j.jamcollsurg.2007.12.029 |
| Popis: | Most reports of donation after cardiac death (DCD) donors are exclusive to kidney transplantation and report high rates of delayed graft function (DGF).From April 1, 2003, to October 3, 2007, we performed 53 kidney transplantations and 4 simultaneous kidney-pancreas transplantations from DCD donors. All DCD donor kidneys were managed with pulsatile perfusion preservation, and all simultaneous kidney-pancreas transplantation donors were managed with extracorporeal support.Of 53 DCD kidney transplantations, 44 (83%) were from standard criteria donors (SCD) and 9 (17%) from expanded criteria donors (ECD). With a mean followup of 12 months, actual patient and kidney graft survival rates were 94% and 87%, respectively. Patient and graft survival rates were 100% in the 4 simultaneous kidney-pancreas transplantations. Incidence of DGF was 57% (60% without versus 20% with extracorporeal support, p = 0.036). Comparison of the 53 DCD donor kidney transplantations with 316 concurrent donation after brain death (DBD) donor adult kidney transplantations (178 SCD, 138 ECD) revealed no differences in demographics or outcomes, except that the DCD donor group had fewer ECDs (17% DCD versus 44% DBD; p = 0.0002), fewer 0-antigen mismatch kidney transplantations (7.5% DCD versus 19% DBD; p = 0.05), and more kidneys preserved with pulsatile perfusion (100% DCD versus 52% DBD; p0.0001). Incidences of DGF (57% DCD versus 19% DBD; p0.0001) and acute rejection (19% DCD versus 10% DBD; p = 0.10) were higher in the DCD donor group, which resulted in a longer initial length of stay (mean 11 days DCD versus 8.0 days DBD; p = 0.006).Despite a high incidence of DGF in the absence of extracorporeal support and greater initial resource use, comparable short-term results can be achieved with DCD and DBD donor kidney transplantations. |
| Databáze: | OpenAIRE |
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