Development of Chemical Biology Tools Focusing on Peptide/Amide Bond Cleavage Reaction
| Autor: | Akira Shigenaga |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
enrichment
Chemical biology Peptide amide bond cleavage Ligands 010402 general chemistry Cleavage (embryo) 01 natural sciences Drug Discovery Humans Molecule Peptide bond peptide bond cleavage labeling chemistry.chemical_classification Molecular Structure 010405 organic chemistry General Chemistry General Medicine Amides Combinatorial chemistry 0104 chemical sciences Amino acid target protein chemistry Target protein Peptides Linker |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 67:1171-1178 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Peptides and proteins are involved in almost all biological events. In this review, three chemical biology tools, which were developed for peptide/protein sciences from a viewpoint of peptide/amide bond cleavage, are overviewed. First, study on an artificial amino acid that enables stimulus-responsive functional control of peptides/proteins is briefly described. Two N–S acyl transfer reaction-based tools, one a linker molecule for facile identification of target proteins of bioactive compounds and the other a reagent for selective labeling of proteins of interest, are then discussed. |
| Databáze: | OpenAIRE |
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