Pathophysiology and Maternal Biologic Markers of Preeclampsia
| Autor: | Joël Girouard, Yves Giguère, Jean-Claude Forest, Jacques Massé, Abdelaziz Kharfi |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population Bioinformatics Preeclampsia Endocrinology Pre-Eclampsia Pregnancy Internal medicine medicine Genetic predisposition Humans Embryo Implantation Endothelial dysfunction education Maternal-Fetal Exchange Biologic marker education.field_of_study Proteinuria business.industry medicine.disease Pathophysiology Vasomotor System Oxidative Stress Blood pressure Female Disease Susceptibility Endothelium Vascular medicine.symptom business Biomarkers |
| Zdroj: | Endocrine. 19:113-126 |
| ISSN: | 0969-711X |
| DOI: | 10.1385/endo:19:1:113 |
| Popis: | Preeclampsia-increased blood pressure and proteinuria appearing after the twentieth week of pregnancy--is a major cause of materal and neonatal morbidity, leading to iatrogenic prematurity. Several lines of evidence suggest that the disorder is owing to diminished invasion of spiral arteries by trophoblastic cells, followed by reduced perfusion of the fetoplacental unit and oxidative stress. These alterations, in the presence of maternal predisposition, lead to endothelial dysfunction and occurrence of the clinical syndrome of preeclampsia (multisystemic lesions). Although the pathophysiology of preeclampsia is still unknown, progress has been made during the past 10 yr, and the early identification of at-risk women with the use of biochemical; ultrasonographic; and, more recently, genetic susceptibility markers has been the subject of intense research. In the present review, markers of maternal predisposition, placental implantation, oxidative stress, vasomotor regulation, and endothelial dysfunction are investigated as candidate markers in the early prediction of preeclampsia. Unfortunately, at the present time, no marker has been proven to have a clinically useful predictive performance in the general pregnant population, and, therefore, more research in that area is warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink