Pediatric renal cell carcinoma
| Autor: | Ardavan Akhavan, Dix P. Poppas, Kiersten Craig |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Urology medicine.medical_treatment 030232 urology & nephrology Antineoplastic Agents urologic and male genital diseases Nephrectomy Young Adult 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma medicine Carcinoma Humans Pediatric Renal Cell Carcinoma Young adult Child Carcinoma Renal Cell Chemotherapy business.industry Immunotherapy Prognosis medicine.disease Kidney Neoplasms Natural history Chemotherapy Adjuvant 030220 oncology & carcinogenesis Lymph Node Excision Lymph business |
| Zdroj: | Current Opinion in Urology. 29:500-504 |
| ISSN: | 0963-0643 |
| DOI: | 10.1097/mou.0000000000000656 |
| Popis: | To review the presentation, natural history and treatment of renal cell carcinoma in children and young adults with renal cell carcinoma (RCC).Complete resection of lymph nodes at the time of tumor resection can improve clinical outcomes and limit the need for adjuvant chemotherapy. Genetic alterations that lead to translocation tumors are a therapeutic target of receptor tyrosine kinase inhibitors.The incidence of RCC increases with age. Unlike adult patients, young patients with RCC present symptomatically and at higher stage and grade. Translocation tumors predominate RCC in children with biologic activity characterized by early spread to lymph nodes with small primary tumors. Preoperative imaging is poorly sensitive for positive lymph nodes; as such, surgeons should have a low threshold for lymph node sampling during tumor resection. Despite the advanced stage at presentation, the prognosis in children is more favorable than their adult counterparts. Complete resection of lymph nodes at the time of surgical resection improves patient prognosis. Chemotherapy targeting the PI3/AKT pathway has demonstrated clinical benefit. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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