Recombinant Factor VIIa for the Prophylaxis of Perioperative Hemorrhage in a Patient With Congenital Factor XI Deficiency Undergoing Brain Tumor Neurosurgery
Autor: | Michael Sabel, Ruediger E. Scharf, Rainer B. Zotz, Christoph Sucker, Walter Stummer, Andrea Gerhardt |
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Rok vydání: | 2007 |
Předmět: |
Male
medicine.medical_specialty Factor XI Deficiency Blood Loss Surgical Brain tumor Factor VIIa law.invention law Activated factor VII Congenital factor XI deficiency medicine Humans Factor XI biology Brain Neoplasms business.industry Hematology General Medicine Perioperative Middle Aged medicine.disease Recombinant Proteins Surgery Recombinant factor VIIa Anesthesia biology.protein Recombinant DNA Neurosurgery business |
Zdroj: | Clinical and Applied Thrombosis/Hemostasis. 14:472-475 |
ISSN: | 1938-2723 1076-0296 |
DOI: | 10.1177/1076029607305119 |
Popis: | The authors report on the first successful use of recombinant activated factor VII for the prophylaxis of bleeding during brain tumor neurosurgery in a patient suffering from inherited factor XI deficiency. Using the agent, surgery was performed without any bleeding complications. In this setting, off-label use of recombinant activated factor VII appears to be a promising alternative for patients suffering from this rare hemostatic defect with hitherto limited therapeutic options. |
Databáze: | OpenAIRE |
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