Improvement on the Performance of Bone Regeneration of Calcium Sulfate Hemihydrate by Adding Mineralized Collagen
| Autor: | Hong-Jun Ai, Huanye Liu, Xi Liu, Fu-Zhai Cui, Li-Ping Zhang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Stromal cell
Biocompatibility Biomedical Engineering Dentistry chemistry.chemical_element Apoptosis Biocompatible Materials Bone Marrow Cells Bioengineering Bone healing Calcium Calcium Sulfate Biochemistry Osseointegration Bone remodeling Biomaterials In vivo Cell Adhesion Animals Bone regeneration Cells Cultured Cell Proliferation Reverse Transcriptase Polymerase Chain Reaction business.industry Chemistry Cell Cycle Durapatite Microscopy Electron Scanning Biophysics Bone Remodeling Collagen Rabbits Stromal Cells business |
| Zdroj: | Tissue Engineering Part A. 16:2075-2084 |
| ISSN: | 1937-335X 1937-3341 |
| Popis: | Comparative investigations of bone regeneration performance for calcium sulfate hemihydrate (CaSO(4).(1/2)H(2)O; CSH) only and CSH with mineralized collagen are reported in this article. The mineralized collagen is the nanohydroxyapatite/collagen (nHAC). The investigations included biocompatibility in vitro and performance of bone repair in vivo. Quantitative and qualitative biocompatibility assays with bone stromal stem cells were performed. A critical box-shaped defect model in the mandible of the rabbit was used to evaluate the bone-remodeling ability of CSH and nHAC/CSH. Results in vitro indicated that the nHAC/CSH significantly improved bioactivity compared with that of CSH, especially in promoting cell adhesion. Further, a higher bone remodeling activity was observed around nHAC/CSH composite than the CSH, especially at the early stage of remodeling. This result means that nHAC/CSH could cause an earlier accelerator and better osseointegration for bone repair than CSH only. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|