Dose modifications of ribociclib and endocrine therapy for treatment of ER+ HER2− metastatic breast cancer
| Autor: | Kristoffer B Kristensen, Tobias Berg, Anders Bonde Jensen, Annette R Kodahl, Ida Marie Nedergaard Thomsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Receptor ErbB-2 medicine.drug_class Dose modifications Aminopyridines Dose reduction Breast Neoplasms Neutropenia 03 medical and health sciences 0302 clinical medicine Breast cancer Breast Neoplasms/drug therapy Internal medicine Ribociclib Antineoplastic Combined Chemotherapy Protocols medicine Humans Progression-free survival Adverse effect Retrospective Studies Aromatase inhibitor Fulvestrant business.industry Antineoplastic Combined Chemotherapy Protocols/adverse effects medicine.disease Metastatic breast cancer Receptor ErbB-2/genetics CDK 4/6 inhibitor 030104 developmental biology Receptors Estrogen Tolerability Purines 030220 oncology & carcinogenesis Female business medicine.drug |
| Zdroj: | Kristensen, K B, Thomsen, I M N, Berg, T, Kodahl, A R & Jensen, A B 2021, ' Dose modifications of ribociclib and endocrine therapy for treatment of ER+ HER2− metastatic breast cancer ', Breast Cancer Research and Treatment, vol. 188, no. 3, pp. 799-809 . https://doi.org/10.1007/s10549-021-06215-6 |
| DOI: | 10.1007/s10549-021-06215-6 |
| Popis: | Purpose: Treatment for estrogen receptor positive (ER+), human epidermal receptor 2 negative (HER2−) metastatic breast cancer (MBC) has improved with the approval of CDK 4/6 inhibitors. Clinical trials with the CDK4/6 inhibitor ribociclib, suggest that 35% to 57.5% of the patients require a dose reduction during ribociclib treatment. Data on the possible consequences of dose reduction concerning efficacy is needed. Methods: A retrospective cohort study on patients with ER+ HER2− MBC from three Danish oncology departments. Data on tolerability and progression-free survival were collected from electronic health records. Results: One hundred and twenty-eight patients with ER+ HER2− MBC who initiated ribociclib treatment between 1st of January 2018 to 31st of March 2020 were included in our analysis. Of these patients, 48.4% required one or more dose reductions. Overall median PFS was 19.2 months (CI-95% 14.3-NR). Patients with one or more dose reductions did not have decreased median PFS (19.2 months, CI-95% 14.3-NR compared to 12.2 months, CI-95% 7.3-NR, p = 0.078). Frequency of adverse events were as previously reported, with grade III and IV neutropenia occurring in 45.3% and 7% of patients, respectively. Patients treated with fulvestrant versus an aromatase inhibitor and patients with lymph node involvement at baseline had lower odds of requiring a dose reduction (ORa = 0.30, CI-95% 0.12–0.73 & ORa = 0.41, CI-95% 0.18–0.89, respectively). Conclusion: Our results indicate that dose reduction of ribociclib is safe and do not compromise the efficacy of the treatment. Furthermore, the study supports translation of results from the MONALEESA trials to patients treated in real-world clinical settings. |
| Databáze: | OpenAIRE |
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