Primary Structure and Biological Activity of Human Brain-Derived Neurotrophic Factor
Autor: | A. ROSENTHAL, D. V. GOEDDEL, T. NGUYEN, E. MARTIN, L. E. BURTON, A. SHIH, G. R. LARAMEE, F. WURM, A. MASON, K. NIKOLICS, J. W. WINSLOW |
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Rok vydání: | 1991 |
Předmět: |
medicine.medical_specialty
Cell Survival Macromolecular Substances Swine Placenta medicine.medical_treatment Molecular Sequence Data Central nervous system Nerve Tissue Proteins Tropomyosin receptor kinase B Biology Polymerase Chain Reaction Fetus Endocrinology Pregnancy Neurotrophic factors Sequence Homology Nucleic Acid Internal medicine medicine Animals Humans Amino Acid Sequence Nerve Growth Factors RNA Messenger Cells Cultured Neurons Brain-derived neurotrophic factor Messenger RNA Base Sequence Brain-Derived Neurotrophic Factor Growth factor Brain Human brain Blotting Northern Recombinant Proteins Nerve growth factor medicine.anatomical_structure nervous system Organ Specificity Female Oligonucleotide Probes |
Zdroj: | Endocrinology. 129:1289-1294 |
ISSN: | 1945-7170 0013-7227 |
Popis: | Brain-derived neurotrophic factor (BDNF) is a 27-kDa basic protein of noncovalently linked 13.5-kD subunits related to nerve growth factor and is produced by the central nervous system (CNS). BDNF has been shown to promote the survival of neurons located in or directly connected with the CNS and is likely to function in adjusting the cell number within neuronal populations to the need of this projection field. Here we describe the primary structure of a human BDNF cDNA, the biological activities of pure recombinant human BDNF, and the tissue distribution of rat BDNF. BDNF mRNA can be found in some peripheral tissues as well as in the CNS, and recombinant human BDNF is a potent neurotrophic factor for primary peripheral sensory neurons. |
Databáze: | OpenAIRE |
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