Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma
| Autor: | Maura Rosane Valério Ikoma, Tatiana Salles de Souza Malaspina, Edgard Jose Franco de Melo, Maria Renata Sales Nogueira Costa, Gustavo Pompermaier Garlet, Karen A. Cavassani, José Humberto Damante, Ana Paula Campanelli, Thaís Helena Gasparoto, João Santana da Silva |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Programmed Cell Death 1 Receptor Immunology Gingiva INFLAMAÇÃO CD8-Positive T-Lymphocytes Peripheral blood mononuclear cell B7-H1 Antigen Immunoenzyme Techniques Lesion Antigens CD Gene expression Tumor Microenvironment medicine Humans Immunology and Allergy Aged Aged 80 and over business.industry Actinic cheilitis Cancer Immunotherapy Middle Aged Flow Cytometry Prognosis Ligand (biochemistry) medicine.disease Survival Rate stomatognathic diseases Cheilitis Oncology Case-Control Studies Carcinoma Squamous Cell Cytokines Female Mouth Neoplasms medicine.symptom Apoptosis Regulatory Proteins business CD8 |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/s00262-011-1007-5 |
| Popis: | PD-1 and PD-L1 can be involved in tumor escape, and little is known about the role of these molecules in oral tumors or pre-malignant lesions. In the present study, we investigated the expression of PD-1 and PD-L1 in the blood and lesion samples of patients with actinic cheilitis (AC) and oral squamous cell carcinoma (OSCC). Our results showed that lymphocytes from peripheral blood and tissue samples exhibited high expression of PD-1 in both groups analyzed. Patients with AC presented higher percentage as well as the absolute numbers of CD4+PD-1+ and CD8+PD-1+ lymphocytes in peripheral blood mononuclear cells (PBMC) than healthy individuals, while patients with OSCC presented an increased frequency of CD8+PD1+ in PBMC when compared with controls. On the other hand, increased frequency of CD4+ and CD8+ T cells expressing PD-1(+) accumulate in samples from OSCC, and the expression of PD-L1 was intense in OSCC and moderate in AC lesion sites. Lower levels of IFN-γ and higher levels of TGF-β were detected in OSCC samples. Our data demonstrate that PD-1 and PD-L1 molecules are present in blood and samples of AC and OSCC patients. Further studies are required to understand the significance of PD-1 and PD-L1 in oral tumors microenvironment. |
| Databáze: | OpenAIRE |
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