Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling
| Autor: | Brian D. Hammann, Marta Zarandi, Andrew V. Schally, Celia A. Kanashiro, Jozsef L. Varga |
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| Rok vydání: | 2004 |
| Předmět: |
MAPK/ERK pathway
Cancer Research medicine.medical_specialty Lung Neoplasms Proto-Oncogene Proteins c-jun Transplantation Heterologous Mice Nude Biology Growth Hormone-Releasing Hormone Protein kinase C signaling Mice chemistry.chemical_compound Internal medicine medicine Animals Humans Carcinoma Small Cell Receptor Protein kinase A Protein Kinase C Protein kinase C Mitogen-Activated Protein Kinase Kinases Bombesin Growth hormone–releasing hormone Endocrinology Oncology chemistry Signal transduction Proto-Oncogene Proteins c-fos Cell Division hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | International Journal of Cancer. 112:570-576 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | We investigated the effects of antagonists of growth hormone-releasing hormone (GHRH) alone and in combination with bombesin/gastrin-releasing peptide (BN/GRP) antagonist RC-3940-II on the growth of H-69 human small cell lung carcinoma (SCLC) xenografted into nude mice. Since the activation of the signaling pathways involving protein kinase C (PKC) and the subsequent steps involving mitogen-activated protein kinase (MAPK) and c-fos and c-jun oncogenes are known to be important mechanisms implicated in cellular growth, we investigated how the blockade of tumoral GHRH receptor splice variants and BN/GRP receptors by these antagonists could interfere with these intracellular signaling pathways. Treatment with GHRH antagonists JV-1-65 or MZ-J-7-110 for 4 weeks significantly (p |
| Databáze: | OpenAIRE |
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