A new immunoradiometric assay (IRMA) system for thyroglobulin measurement in the follow-up of thyroid cancer patients
| Autor: | Jean Lumbroso, P. Gardet, Philippe Fragu, M. Schlumberger, Claude Parmentier, D. Violot |
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| Rok vydání: | 1991 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Urology Monoclonal antibody Sensitivity and Specificity Thyroglobulin Thyroid carcinoma Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Thyroid Neoplasms Thyroid cancer Thyroglobulin Measurement Immunoradiometric assay business.industry Thyroidectomy Radioimmunoassay General Medicine medicine.disease Endocrinology Immunoradiometric Assay business Follow-Up Studies |
| Zdroj: | European Journal of Nuclear Medicine. 18:153-157 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/bf02262724 |
| Popis: | A new commercially available kit for thyroglobulin (Tg) measurement [immunoradiometric assay (IRMA) system based on monoclonal antibodies] was used in 479 patients with thyroid carcinoma. The effective working range was 1 ng/ml, and results were strongly correlated with our homemade radioimmunoassay (RIA). This IRMA method is less susceptible to interferences of auto-antibodies than our RIA. During thyroxine (T4) treatment, the Tg level was undetectable in 98% of patients after total thyroid ablation, in 91% after total thyroidectomy and in 42% after lobectomy only. In this situation, Tg was found in all patients with large metastases and in 88% of those with small metastases. Following T4 withdrawal, Tg was detectable in all patients with neoplastic disease and in 13% of those in complete remission after total thyroid ablation. In conclusion, Tg measured with this IRMA method appears to be a reliable marker of differentiated thyroid carcinoma. |
| Databáze: | OpenAIRE |
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