Temporal changes of the plasma levels of cystatin C, β‐trace protein, β2‐microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process
| Autor: | Christopher W. Schmidt, Dag Wide-Swensson, Helena Strevens, Veronica Lindström, Anders Grubb, Søren Blirup-Jensen, Karl Kristensen |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Clinical Biochemistry Renal function Kidney chemistry.chemical_compound Pregnancy Reference Values Internal medicine medicine Humans Cystatin C Pregnancy Trimesters Creatinine biology Beta-2 microglobulin Kidney metabolism General Medicine medicine.disease Cystatins Lipocalins Uric Acid Intramolecular Oxidoreductases Endocrinology chemistry biology.protein Uric acid Female beta 2-Microglobulin Biomarkers Glomerular Filtration Rate |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 67:612-618 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365510701203488 |
| Popis: | To determine the plasma levels of the renal functional markers creatinine, urate, cystatin C, beta2-microglobulin and beta-trace protein in samples from the first, second, early third and late third trimesters of 398 healthy women with uncomplicated singleton pregnancies.Plasma samples from 58 healthy non-pregnant women served as controls. The creatinine levels were significantly lower at all time-points in pregnancy, whereas the urate levels were lower during the first and second trimesters but increased in the late third trimester. The cystatin C, beta2-microglobulin and beta-trace protein levels displayed similar changes with increased levels in the third trimester but unaltered levels during the first and second trimesters.The results indicate an increased filtration of low-molecular weight molecules during pregnancy, particularly during the first and second trimesters, whereas filtration of 10-30 kDa molecules is decreased in the third but unaltered in the first and second trimesters. The levels of albumin and alph2-macroglobulin were measured in the same samples.The albumin levels decreased in the second and third trimesters, whereas the levels of chi2-macroglobulin were unchanged, which is compatible with a virtually unaltered transfer of chi2-macroglobulin between the intra- and extravascular space during pregnancy and a significantly increased extravascular fraction of albumin. |
| Databáze: | OpenAIRE |
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