Quantification of the virus-host interaction in human T lymphotropic virus I infection

Autor: Graham P. Taylor, Yuetsu Tanaka, Charles R. M. Bangham, Angelina J. Mosley, Becca Asquith, Angela R. McLean, Adrian Heaps
Jazyk: angličtina
Rok vydání: 2016
Předmět:
HTLV-1-ASSOCIATED MYELOPATHY
Cell
NEUROLOGIC DISEASE
Disease
LYMPHOCYTES
medicine.disease_cause
Zoological sciences
Pathogenesis
0302 clinical medicine
Proviruses
immune system diseases
GENE-EXPRESSION
0303 health sciences
biology
virus diseases
Gene Products
tax
Middle Aged
Viral Load
3. Good health
Infectious Diseases
medicine.anatomical_structure
Carrier State
Antibody
Life Sciences & Biomedicine
Viral load
Adult
lcsh:Immunologic diseases. Allergy
Viral protein
PROVIRAL LOAD
Immunology
PERIPHERAL-BLOOD
03 medical and health sciences
Virology
TAX PROTEIN
medicine
Humans
RNA
Messenger
Aged
030304 developmental biology
Science & Technology
Research
1103 Clinical Sciences
HTLV-I
HTLV-I Infections
CD4 Lymphocyte Count
biology.protein
TROPICAL SPASTIC PARAPARESIS
lcsh:RC581-607
Asymptomatic carrier
CD8
CELL LEUKEMIA-VIRUS
T-Lymphocytes
Cytotoxic
030215 immunology
Zdroj: Retrovirology, Vol 2, Iss 1, p 75 (2005)
Retrovirology
DOI: 10.1186/1742-4690-2-75
Popis: BackgroundHTLV-I causes the disabling inflammatory disease HAM/TSP: there is no vaccine, no satisfactory treatment and no means of assessing the risk of disease or prognosis in infected people. Like many immunopathological diseases with a viral etiology the outcome of infection is thought to depend on the virus-host immunology interaction. However the dynamic virus-host interaction is complex and current models of HAM/TSP pathogenesis are conflicting. The CD8+ cell response is thought to be a determinant of both HTLV-I proviral load and disease status but its effects can obscure other factors.ResultsWe show here that in the absence of CD8+ cells, CD4+ lymphocytes from HAM/TSP patients expressed HTLV-I protein significantly more readily than lymphocytes from asymptomatic carriers of similar proviral load (P = 0.017). A high rate of viral protein expression was significantly associated with a large increase in the prevalence of HAM/TSP (P = 0.031, 89% of cases correctly classified). Additionally, a high rate of Tax expression and a low CD8+ cell efficiency were independently significantly associated with a high proviral load (P = 0.005, P = 0.003 respectively).ConclusionThese results disentangle the complex relationship between immune surveillance, proviral load, inflammatory disease and viral protein expression and indicate that increased protein expression may play an important role in HAM/TSP pathogenesis. This has important implications for therapy since it suggests that interventions should aim to reduce Tax expression rather than proviral loadper se.
Databáze: OpenAIRE
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