Human γ-interferon expression in the mammary gland of transgenic mice
| Autor: | V.P. Kuznetsov, I.S. Frolova, Oleg V. Lagutin, Vasily N. Dobrovolsky, Oleg A. Larionov, T.V. Vinogradova |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Genetically modified mouse
Ratón Recombinant Fusion Proteins Transgene Molecular Sequence Data Mammary gland Biophysics Gene Expression Mice Transgenic Lactoglobulins Biology β-Lactoglobulin Biochemistry Interferon-gamma Mice Mammary Glands Animal Transgenic mouse Structural Biology Complementary DNA Lactation Gene expression Genetics medicine Animals Humans Interferon gamma RNA Messenger Molecular Biology γ-Interferon Base Sequence DNA Cell Biology Molecular biology Ovine Milk medicine.anatomical_structure Female Human medicine.drug |
| Zdroj: | FEBS Letters. 319:181-184 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(93)80063-z |
| Popis: | Transgenic mice carrying a hybrid gene consisting of ovine β-lactoglobulin gene sequences and human γ-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800 IUml. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male. |
| Databáze: | OpenAIRE |
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