The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease
| Autor: | Patrizia Zentilin, Giorgio Sammito, Luca Maria Sconfienza, Marzio Frazzoni, Edoardo Savarino, Vincenzo Savarino, Elisa Marabotto, Lorenzo Gemignani, Alberto Malesci, Lorenzo Assandri, Daria Bonfanti |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Impedance–pH monitoring medicine.medical_specialty Esophageal pH Monitoring Adolescent NERD Nerd Population Functional heartburn Disease Gastroenterology Endoscopy Gastrointestinal Body Mass Index Diagnosis Differential Young Adult Heartburn Internal medicine Electric Impedance medicine Humans education Aged Impedance pH-metry education.field_of_study Hepatology business.industry Non-Acid Reflux digestive oral and skin physiology Reflux Reproducibility of Results Middle Aged Rome iii digestive system diseases Gastroesophageal Reflux Female Proton pump inhibitor therapy business |
| Zdroj: | Digestive and Liver Disease. 43:542-547 |
| ISSN: | 1590-8658 |
| DOI: | 10.1016/j.dld.2011.01.016 |
| Popis: | Introduction Functional heartburn is defined by Rome III criteria as an endoscopy-negative condition with normal oesophageal acid exposure time, negative symptom association to acid reflux and unsatisfactory response to proton pump inhibitors. These criteria underestimated the role of non-acid reflux. Aim To assess the contribution of impedance-pH with symptom association probability (SAP) analysis in identifying endoscopy-negative patients with reflux disease and separating them from functional heartburn. Methods Consecutive endoscopy-negative patients treated with proton pump inhibitors ( n = 219) undergoing impedance-pH monitoring off-therapy were analysed. Distal acid exposure time, reflux episodes, SAP and symptomatic response to proton pump inhibitors were measured. Results Based on impedance-pH/SAP, 67 (31%) patients were pH+/SAP+, 6 (2%) pH+/SAP−, 83 (38%) hypersensitive oesophagus and 63 (29%) functional heartburn. According to pH-metry alone/response to proton pump inhibitors, 62 (28%) were pH+/SAP+, 11 (5%) pH+/SAP−, 61 (28%) hypersensitive oesophagus and 85 (39%) functional heartburn. In the normal-acid exposure population the contribution of impedance-pH/SAP compared to pH-metry alone/response to proton pump inhibitors in identifying patients with reflux disease and functional heartburn resulted to be 10%. In patients with abnormal-acid exposure, the contribution of impedance-pH/SAP increased by 3%. Conclusion Comparing impedance-pH testing with pH-metry alone plus the response to proton pump inhibitor therapy demonstrated that the latter ones cause underestimation of reflux disease patients and overestimation of functional heartburn patients. |
| Databáze: | OpenAIRE |
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