Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study
| Autor: | Mingxiu Luo, Q. Fu, Joanne M. Jordan, Junling Cao, Bruce Caterson, Virginia B. Kraus, Victor Colin Duance, Jordan B. Renner |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male musculoskeletal diseases Hand Joints Biomedical Engineering Osteoarthritis Thumb Metacarpal bones Severity of Illness Index Radiographic Article 03 medical and health sciences 0302 clinical medicine Rheumatology Finger Joint Diagnosis Deformity medicine medicine.bone Humans Orthopedics and Sports Medicine 030212 general & internal medicine 030203 arthritis & rheumatology 2. Zero hunger Orthodontics Kashin-Beck Disease Kashin–Beck disease business.industry Anatomy Phalanx Middle Aged medicine.disease Hand 3. Good health Radiography medicine.anatomical_structure First metacarpal bone Finger joint Female medicine.symptom business |
| Zdroj: | Osteoarthritis and Cartilage. 23(6):868-873 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2015.01.009 |
| Popis: | Objective Kashin-Beck Disease (KBD) is a rare and severe osteoarthropathy endemic to China. We evaluated the frequency and patterns of hand radiographic osteoarthritis (rOA) in adults with and without KBD. Methods Han Chinese (N = 438) from Yongshou County of central China underwent right hand radiography for determining case status. Presence of KBD was based on characteristic radiographic deformities of articular ends of bones including articular surface depression, carpal crowding, any subchondral bone deformities in the proximal end of phalanges or first metacarpal bone, or the distal ends of metacarpal bones 2–5, and any bony enlargement with deformity of the distal ends of phalanges. Hand rOA severity was determined by osteophyte (OST), joint space narrowing (JSN), and Kellgren and Lawrence (KL) grades. Results This study included 127 KBD and 311 non-KBD adults of similar mean age (39 years) and body mass index (BMI) (21 kg/m2). Inter- and intra-rater reliability for radiographic determination of case status and rOA features was high (kappa 0.72–0.96). Compared to non-KBD, KBD adults had significantly more severe hand rOA of the thumb, distal interphalangeal (DIP), proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joints. Only KBD adults had end-stage carpometacapal (CMC) disease. In KBD, DIPs and PIPs were more affected than MCPs and the frequency of OSTs was significantly higher in PIPs than DIPs. Conclusions Compared with age-matched adults from the same area and farming occupation, KBD hand rOA was more widespread and severe, particularly of PIPs and CMCs. The ability to differentiate adult KBD from non-KBD hand rOA will facilitate genetic analyses of the vast majority of affected individuals. |
| Databáze: | OpenAIRE |
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