Noradrenergic mechanisms in the central amygdalar nucleus and gastric stress ulcer formation in rats
| Autor: | Ronald M. Sullivan, Arunabha Ray, Peter G. Henke |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Restraint Physical medicine.medical_specialty Microinjections Propranolol Clonidine Norepinephrine Internal medicine Prazosin Medicine Neurotoxin Animals Stomach Ulcer business.industry General Neuroscience Stress ulcer Stomach Antagonist Rats Inbred Strains medicine.disease Amygdala digestive system diseases Rats Endocrinology medicine.anatomical_structure Catecholamine business Adrenergic Fibers Stress Psychological medicine.drug |
| Zdroj: | Neuroscience letters. 110(3) |
| ISSN: | 0304-3940 |
| Popis: | Microinjections of noradrenaline (NA, 0.3, 3.0 and 30.0 micrograms) into the central amygdalar nucleus (CEA) produced dose-related attenuations of cold restraint (3 h at 4 degrees C) induced gastric ulcer formation in rats. On the other hand, stress ulcer aggravating effects were seen with beta-adrenoceptor antagonist, propranolol (10 micrograms) but not with the alpha-adrenoceptor antagonist, prazosin (1 and 10 micrograms). Moderate enhancements of gastric stress lesions were also seen with the NA release inhibitor clonidine (1 microgram) and the neurotoxin DSP-4 (25 micrograms). Further, pretreatment of rats with intra-amygdalar (i.am.) propranolol but not prazosin, antagonized and reversed the gastric cytoprotective effects of NA. The results indicate that beta-adrenoceptor-mediated NAergic mechanisms at the level of the CEA are important for the maintenance of gastric mucosal integrity during immobilization stress. |
| Databáze: | OpenAIRE |
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