Induction of apoptotic cell DNA fragmentation in human cells after treatment with hyperthermia

Autor:	Joshua James Fairbairn, Kirk Joseph Ward, Kim L. O'Neill, D.W. Fairbairn, Brian Willard Loveridge, Mohammad Waleed Khan
Rok vydání:	1995
Předmět:	Cancer Research Programmed cell death Hot Temperature Time Factors DNA damage Hyperthermia Treatment Apoptosis Biology Burkitt Lymphoma Molecular biology Raji cell Cell biology Comet assay Oncology Tumor Cells Cultured Humans DNA fragmentation Fragmentation (cell biology) DNA Damage
Zdroj:	Cancer Letters. 89:183-188
ISSN:	0304-3835
DOI:	10.1016/0304-3835(94)03668-9
Popis:	The biological significance of apoptosis is becoming increasingly clear. Its relevance in tumor response to treatment as well as recent evidence for its important function as a regulating mechanism in tumorigenesis has also been demonstrated. One of the most prominent biological features of apoptosis is nucleosomal DNA fragmentation. In this communication, we present a study of DNA fragmentation in Raji cells which have been subjected to hyperthermia treatment to induce apoptosis. We found that the induction and onset of fragmentation is swift, and consistent with previous reports that fragmentation must be a rapid event.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b944eb2aa57403bb6af39a23bff3b47d https://doi.org/10.1016/0304-3835(94)03668-9 Zobrazit plný text záznamu Full Text from ScienceDirect