Successful treatment of tumour-induced osteomalacia after resection of an oral peripheral ossifying fibroma
| Autor: | Romelito Jose Galsim, Jose M. Carnate, Rafael C Bundoc, Majorie Amoroto Palermo, Mark Anthony Santiago Sandoval, Ryner Jose D. Carrillo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Paraneoplastic Syndromes Ulna 030209 endocrinology & metabolism urologic and male genital diseases Gastroenterology Article Resection 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Internal medicine Vitamin D and neurology Humans Medicine Kyphosis Metatarsal Bones Neoplasms Connective Tissue Osteomalacia business.industry Tumour-induced osteomalacia Peripheral ossifying fibroma General Medicine Humerus Metacarpal Bones medicine.disease Magnetic Resonance Imaging Radiography Mandibular Neoplasms 030104 developmental biology Fibroma Ossifying Disease Progression Fibroma business Rare disease Hormone |
| Zdroj: | BMJ Case Reports. :bcr2016218637 |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2016-218637 |
| Popis: | Tumour-induced osteomalacia is a paraneoplastic syndrome wherein bone is affected by a hormone from a tumour that causes renal phosphate wasting and hypophosphataemia. Here, we present the case of a 31-year-old man who has been suffering from generalised bone pains and a spine deformity that led to loss of height. Pertinent findings are low serum phosphorus, low vitamin D and decreased bone mineral density. These findings led to a diagnosis of osteomalacia. However, the finding of an oral mass raised some questions as to what role it plays in the patient's disease. It was suspected that the oral mass (fibroma) was producing a hormone that led to renal phosphate wasting, hypophosphataemia and then osteomalacia. This hypothesis was proven after surgical removal of the mass led to normalisation of the metabolic derangements and eventually led to a resolution of the bone pains. |
| Databáze: | OpenAIRE |
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