Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India
| Autor: | Radhika K. Nagaraj, Vijay V. Kakkar, Sridhara Hebbagodi, Veena S. Rao, Natesha B. Kadarinarasimhiah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
education.field_of_study lcsh:Diseases of the circulatory (Cardiovascular) system Article Subject Traditional medicine business.industry Population Neopterin Disease medicine.disease_cause medicine.disease Gastroenterology Proinflammatory cytokine chemistry.chemical_compound chemistry lcsh:RC666-701 Internal medicine medicine Metabolic syndrome Risk factor Cardiology and Cardiovascular Medicine education business Oxidative stress Research Article |
| Zdroj: | Cardiology Research and Practice, Vol 2011 (2011) Cardiology Research and Practice |
| ISSN: | 2090-0597 |
| Popis: | Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P<.0001), Neopterin (P=.036), and oxLDL (P<.0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810;P<.0001) followed by hsCRP (OR 1.324 95% CI 1.070–1.638;P=.010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population. |
| Databáze: | OpenAIRE |
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