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Phylogeny of sine oculis-homeobox (SIX-HD) transcription factors. The homeodomain (HD) and SIX domains of SIX-HD proteins of H. sapiens, D. melanogaster, E. multilocularis, and H. microstoma were aligned together with published planarian SIX-HD proteins, and a phylogeny was estimated by Maximum Likelihood analysis (with a JTT model) using MEGA 5.2 [85]. Bootstrap support values from 1,000 replicates are indicated next to the nodes. Genbank accession codes are given for H. sapiens, D. melanogaster, and for the planarians S. mediterranea and G. tigrina; GeneDB accession codes are given for E. multilocularis and H. microstoma. Different groups of SIX-HD proteins are outlined, and the six3/6 genes of E. multilocularis and H. microstoma are indicated by arrows. (PDF 109 kb) |
