Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter
| Autor: | Grace Kusumawidjaja, Eduard Ryschich, Akmal Khamidjanov, Markus W. Büchler, Ingrid Herr, Wolfgang Gross, Gerhard Moldenhauer, Helge Bruns, Alexei V. Salnikov, Peter Schemmer, Martha-Maria Gebhard, Vanessa Rausch |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Carcinoma Hepatocellular Colorectal cancer Fluorescent Antibody Technique Immunophenotyping Antigens CD Cancer stem cell Biomarkers Tumor Carcinoma medicine Humans neoplasms Aged biology business.industry CD24 Liver Neoplasms CD44 Cancer Middle Aged Prognosis medicine.disease carbohydrates (lipids) Oncology Hepatocellular carcinoma embryonic structures Neoplastic Stem Cells biology.protein Female Colorectal Neoplasms business |
| Zdroj: | Cancer Letters. 275:185-193 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2008.10.015 |
| Popis: | Recent findings suggest that the presence of cancer stem cells could be linked with patients' survival. We profiled suggested cancer stem cell markers in tissue specimens of hepatocellular carcinoma and colorectal carcinoma liver metastases. About 1% of cells co-expressed cancer stem cell antigens, but there was no correlation between the amount of CD133(+), CD133(+)/CD44(+) or CD133(+)/CD24(-) cells and the patients' clinical-pathological status or with the cancer stem cell marker-positive cells localization. CD133(+) and CD133(-) fractions of Huh7 cells did not differ in migratory properties. Therefore, presence of markers alone should be taken with caution as single prognostic parameters. |
| Databáze: | OpenAIRE |
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