TRPA1 participation in behavioral impairment induced by chronic corticosterone administration

Autor: Gabriele Cheiran Pereira, Elisa Piton, Jéssica Bornholdt, Brenda Moreira dos Santos, Amanda Spring de Almeida, Diéssica Padilha Dalenogare, Maria Fernanda Pessano Fialho, Gabriela Becker, Evelyne da Silva Brum, Tuane Bazanella Sampaio, Sara Marchesan Oliveira, Mauro Schneider Oliveira, Gabriela Trevisan, Guilherme Vargas Bochi
Rok vydání: 2022
Předmět:
Zdroj: Psychopharmacology. 240:157-169
ISSN: 1432-2072
0033-3158
DOI: 10.1007/s00213-022-06290-7
Popis: Major depressive disorder (MDD) is one of the most diagnosed mental disorders. Despite this, its pathophysiology remains poorly understood. In this context, basic research aims to unravel the pathophysiological mechanisms of MDD as well as investigate new targets and substances with therapeutic potential. Transient receptor potential ankyrin 1 (TRPA1) is a transmembrane channel considered a sensor for inflammation and oxidative stress. Importantly, both inflammation and oxidative stress have been suggested as participants in the pathophysiology of MDD. However, the potential participation of TRPA1 in depressive disorder remains poorly investigated.To investigate the involvement of the TRPA1 channel in the behavioral changes induced by chronic corticosterone administration (CCA) in male mice.Swiss male mice were exposed to 21 days of CCA protocol and then treated with HC-030031 or A-967079, TRPA1 antagonists. Behavioral tests, analyzes of oxidative parameters and TRPA1 immunocontent were performed in the prefrontal cortex (PFC) and hippocampus (HIP).CCA induced despair-like behavior in mice accompanied by an increase in the levels of hydrogen peroxide (HOur work suggests that TRPA1 channel appears crucial to mediate the behavioral impairment induced by CCA in male Swiss mice.
Databáze: OpenAIRE
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