Therapy evaluation of laryngeal carcinomas by tyrosine-PET

Autor: Willem Vaalburg, Jurjan R. de Boer, Allard Krikke, Fred R. Burlage, Jan Pruim, Anton T. M. G. Tiebosch, Frans W. J. Albers, Bernard F. A. M. van der Laan
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Man, Biomaterials and Microbes (MBM)
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Male
Larynx
Neoplasm
Residual
L-[1-C-11]-tyrosine (TYR)
BRAIN-TUMORS
medicine.medical_treatment
protein synthesis rate (PSR)
laryngeal carcinoma
Physical examination
Sensitivity and Specificity
Tumor Status
POSITRON-EMISSION-TOMOGRAPHY
NECK-CANCER
Predictive Value of Tests
PROTEIN-SYNTHESIS RATE
SYNTHESIS RATES
Biopsy
medicine
Humans
Carbon Radioisotopes
positron emission tomography (PET)
HEAD
Laryngeal Neoplasms
IN-VIVO
Aged
Aged
80 and over
medicine.diagnostic_test
business.industry
L-<1-C-11>TYROSINE PET
Middle Aged
Endoscopy
Radiation therapy
C-11 METHIONINE
medicine.anatomical_structure
Otorhinolaryngology
Epidermoid carcinoma
therapy evaluation
Positron emission tomography
Carcinoma
Squamous Cell
Feasibility Studies
Tyrosine
Female
SQUAMOUS-CELL CARCINOMA
Neoplasm Recurrence
Local
Radiopharmaceuticals
Nuclear medicine
business
Tomography
Emission-Computed
Zdroj: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck, 25(8), 634-644. Wiley
ISSN: 1097-0347
1043-3074
Popis: Introduction. One of the major problems in head and neck oncology is determination of tumor status after radiotherapy. Physical examination and conventional imaging by CT and MRI do not always accurately differentiate between residual or recurrent tumor and posttreatment inflammation, fibrosis, edema, or scarring. The feasibility of positron emission tomography (PET) with L-[1-C-11]-tyrosine (TYR) for therapy evaluation of laryngeal squamous cell carcinomas by identification of residual or recurrent disease after radiotherapy was investigated.Patients and Methods. Nineteen patients with laryngeal carcinomas had standard workups with endoscopy and conventional imaging. All subjects underwent a TYR PET scan (PET1) before definitive treatment. For determination of tumor status, a second TYR PET scan (PET2) was performed 3 months after radiotherapy, At the time of scanning, seven patients were clinically suspected of having residual disease, and in these cases, additional CT imaging and biopsies during endoscopy were performed. During the minimal follow-up period of 29 months, six patients had clinical suspicion of recurrent disease. In these six cases, a third TYR PET (PET3), CT imaging, and biopsy were performed.Results, All pretreatment tumors were depicted by TYR PET (PET1). Three months after radiotherapy, sensitivity and specificity of TYR PET (PET2) for discrimination between residual tumor and benign posttreatment tissue changes were both 100%, and for CT, 50% and 67%, respectively. For detection of recurrent tumor during follow-up, sensitivity and specificity of TYR PET (PET3) were also 100%, and CT, 75% and 50%, respectively.Conclusions. Dynamic TYR PET is an accurate imaging modality for therapy evaluation in detection of residual and recurrent disease with higher sensitivity (100%) and specificity (100%) for discrimination of tumor status by TYR PET compared with conventional imaging. (C) 2003 Wiley Periodicals, Inc.
Databáze: OpenAIRE
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