Placental arsenic concentrations in relation to both maternal and infant biomarkers of exposure in a US cohort
| Autor: | David C Conway, Emily R. Baker, Matthew A. Davis, Brian P. Jackson, Tracy Punshon, Margaret R. Karagas, Shaleen K. Theiler, Carmen J. Marsit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
inorganic chemicals
Adult Male medicine.medical_specialty Epidemiology Urinary system Placenta Physiology chemistry.chemical_element Toxicology Article Arsenic Pregnancy medicine Humans New Hampshire reproductive and urinary physiology integumentary system business.industry Obstetrics Drinking Water Public Health Environmental and Occupational Health Infant Environmental exposure Environmental Exposure medicine.disease Pollution medicine.anatomical_structure chemistry Nails In utero Cohort embryonic structures Gestation Female business Biomarkers |
| Popis: | Arsenic crosses the placenta and may have adverse consequences in utero and later in life. At present, little is known about arsenic concentrations in placenta and their relation to maternal and infant exposures particularly at common levels of exposure. We measured placenta arsenic in a US cohort potentially exposed via drinking water from private wells, and evaluated the relationships between placenta and maternal and infant biomarker arsenic concentrations. We measured total arsenic concentrations in placental samples from women enrolled in the New Hampshire Birth Cohort Study (N=766). We compared these data to maternal urinary arsenic (total arsenic and individual species) collected at approximately 24-28 week gestation, along with maternal post-partum toenails and infant toenails using non-parametric multivariate analysis of log10-transformed data. We also examined the association between placental arsenic and household drinking water arsenic. Placenta arsenic concentrations were related to arsenic concentrations in maternal urine (β 0.55, P value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|