Bone Turnover Markers in Patients With Nonalcoholic Fatty Liver Disease and/or Type 2 Diabetes During Oral Glucose and Isoglycemic Intravenous Glucose
| Autor: | Lise Lotte Gluud, Tina Vilsbøll, Niklas Rye Jørgensen, Henrik Maagensen, Anders Ellekær Junker, Filip K. Knop |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose Male endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Administration Oral Type 2 diabetes Biochemistry Bone remodeling Cohort Studies Liver disease 0302 clinical medicine Endocrinology Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease Glucose tolerance test biology medicine.diagnostic_test Middle Aged Bone Remodeling/physiology Osteocalcin Administration Intravenous Female Bone Remodeling Diabetes Mellitus Type 2/blood Adult medicine.medical_specialty 030209 endocrinology & metabolism Context (language use) 03 medical and health sciences Blood Glucose/drug effects Internal medicine Diabetes mellitus medicine Humans Aged business.industry Biochemistry (medical) nutritional and metabolic diseases Glucose Tolerance Test medicine.disease Glucose/administration & dosage 030104 developmental biology Cross-Sectional Studies Glucose Diabetes Mellitus Type 2 Non-alcoholic Fatty Liver Disease/blood biology.protein business Biomarkers/blood Biomarkers |
| Zdroj: | BASE-Bielefeld Academic Search Engine Maagensen, H, Junker, A E, Jørgensen, N R, Gluud, L L, Knop, F K & Vilsbøll, T 2018, ' Bone Turnover Markers in Patients with Nonalcoholic Fatty Liver Disease and/or Type 2 Diabetes during Oral Glucose and Isoglycemic Intravenous Glucose ', Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 5, pp. 2042-2049 . https://doi.org/10.1210/jc.2018-00176 |
| ISSN: | 1945-7197 |
| DOI: | 10.1210/jc.2018-00176 |
| Popis: | Context: Nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes (T2D) and vice versa, and both conditions are associated with an increased risk of fractures and altered bone turnover. Although patients with NAFLD typically suffer from decreased bone mineral density (BMD), T2D is associated with normal to high BMD. The pathophysiology is uncertain but may involve the gut-bone axis. Objective: We investigated the influence of the gut on glucose-induced changes in plasma bone turnover markers in healthy controls and patients with T2D and/or biopsy-verified NAFLD. Design: Cross-sectional cohort study. Patients: Patients with NAFLD with normal glucose tolerance, patients with NAFLD and T2D, patients with T2D without liver disease, and healthy controls. Interventions: Four-hour 50-g oral glucose tolerance test (OGTT) and an isoglycemic intravenous glucose infusion (IIGI). Main Outcome Measures: Collagen type 1 C-telopeptide (CTX), osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), and parathyroid hormone. Results: Plasma glucose levels achieved during OGTTs were successfully matched on corresponding IIGI days. Patients with NAFLD and T2D exhibited similar CTX suppression during the two glucose challenges (P = 0.46) and pronounced suppression of P1NP during IIGI compared with OGTT. Conversely, remaining groups showed greater (P < 0.05) CTX suppression during OGTT and similar suppression of bone formation markers during IIGI and OGTT. Conclusions: OGTT-induced CTX suppression seems to be impaired in patients with NAFLD and T2D, but preserved in patients with either NAFLD or T2D, suggesting that coexistence of T2D and NAFLD may affect gut-bone axis. |
| Databáze: | OpenAIRE |
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