Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum
| Autor: | Esther Peña, Pablo Sutelman, Guiomar Mendieta, Gemma Vilahur, Maria Borrell-Pages, Lina Badimon, Laura Casaní, Soumaya Ben-Aicha, Javier Crespo |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Swine Myocardial Infarction 030204 cardiovascular system & hematology Triglyceride Intestinal absorption Antioxidants Silybum marianum 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Milk Thistle Myocardial infarction Ventricular remodeling Receptor Triglycerides biology medicine.diagnostic_test Ventricular Remodeling business.industry Myocardium medicine.disease biology.organism_classification Lipid receptors Disease Models Animal 030104 developmental biology Endocrinology chemistry Lipotoxicity Cardiology and Cardiovascular Medicine Lipid profile business |
| Zdroj: | ATHEROSCLEROSIS r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1879-1484 0021-9150 |
| Popis: | Background and aims Silybum marianum (SM) is an herbal product with cytoprotective and antioxidant properties. We have previously demonstrated that SM ameliorates ventricular remodeling and improves cardiac performance. Here, we evaluated whether SM could exert beneficial effects against cardiac lipotoxicity in a pig model of closed-chest myocardial infarction (MI). Methods Study 1 investigated the effect of SM administration on lipid profile and any potential SM-related adverse effects. Animals received SM or placebo during 10 days and were afterward sacrificed. Study 2 evaluated the effectiveness of SM daily administration in reducing cardiac lipotoxicity in animals subjected to a 1.5h myocardial infarction (MI), who were subsequently reperfused for 2.5h and euthanized or kept under study for three weeks and then sacrificed. Results Animals administered a 10-day SM regime presented a sharp decline in plasma triglyceride levels vs. controls, with no other modifications in lipid profile. The decrease in triglyceride concentration was accompanied by a marked reduction in triglyceride intestinal absorption and glycoprotein-P expression. Three weeks post-MI the triglyceride content in the ischemic myocardium of the SM-treated animals was significantly lower than in the ischemic myocardium of placebo-controls. This effect was associated with an enhanced cardiac expression of PPARγ and triglyceride clearance receptors. This long-term SM-administration induced a lower expression of lipid receptors in subcutaneous adipose tissue. No SM-related side-effects were registered. Conclusion SM administration reduces plasma triglyceride levels through attenuation of triglyceride intestinal absorption and modulates cardiac lipotoxicity in the ischemic myocardium, likely contributing to improve ventricular remodeling. |
| Databáze: | OpenAIRE |
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