New chromatographic insights on drug:cyclodextrin inclusion complexes and their potential use in drug delivery
| Autor: | Marieta, Constantin, Bogdan, Cosman, Paolo, Ascenzi, Bogdan C, Simionescu, Gheorghe, Fundueanu |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Expert Opinion on Drug Delivery. 19:1696-1709 |
| ISSN: | 1744-7593 1742-5247 |
| DOI: | 10.1080/17425247.2022.2147159 |
| Popis: | Cyclodextrins (CDs) play a pivotal role in the controlled release of drugs; however, their ability to gradually release drugs is here interrogated: can cyclodextrins, even those that form strong inclusion complexes, sustain a prolonged release of drugs?An original chromatographic approach was developed and accordingly we classified and determined drugs that form the most stable inclusion complexes with cyclodextrins. β-CD and hydroxypropyl-β-CD (HP-β-CD) were coupled to pullulan (Pul) microspheres and packed into a chromatographic column. Then, different drugs or model compounds were eluted, and values of the retention time (The drugs with the longestIf the dissociation of the guest molecule is very rapid, why is it expected that these complexes gradually release the drug? |
| Databáze: | OpenAIRE |
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