Effects of ionized waterfall aerosol on pediatric allergic asthma
| Autor: | Arnulf Hartl, Markus Ritter, Amina Selimovic, P. Kolarž, Josef Thalhamer, Heidemarie Dobias, Isidor Huttegger, Renata Sanovic, Angelika Moder, Martin Gaisberger |
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| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Male Adolescent Nitric Oxide T-Lymphocytes Regulatory law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Immunology and Allergy Medicine Humans Child 030304 developmental biology Asthma Aerosols 0303 health sciences medicine.diagnostic_test business.industry Interleukins Water Allergic asthma respiratory system Effects of high altitude on humans Immunoglobulin E medicine.disease respiratory tract diseases 3. Good health Aerosol Clinical trial 030228 respiratory system Breath Tests Anesthesia Pediatrics Perinatology and Child Health Exhaled nitric oxide Camping Female business |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 49(8) |
| ISSN: | 1532-4303 |
| Popis: | Ionized water aerosols have been suggested to exert beneficial health effects on pediatric allergic asthma. Their effect was evaluated in a randomized controlled clinical trial as part of a summer asthma camp.Asthmatic allergic children (n = 54) spent 3 weeks in an alpine asthma camp; half of the group was exposed to water aerosol of an alpine waterfall for 1 hour per day, whereas the other half spent the same time at a "control site". Immunological analysis, lung function testing, and fractional exhaled nitric oxide (FeNO) testing were performed during the stay, and sustaining effects were evaluated 2 months later. Symptom score testing was done over a period of 140 days.The water aerosol group showed a significant improvement in all lung function parameters, whereas only the peak expiratory flow improved in the control group. All patients showed a significant improvement in symptom score and a significant decrease in FeNO after the camp. Only the water aerosol group exhibited a long-lasting effect on asthma symptoms, lung function, and inflammation in the follow-up examination. Induction of interleukin (IL)-10 and regulatory T (Treg) cells was measured in both groups, with a pronounced increase in the water aerosol group. IL-13 was significantly decreased in both groups, whereas IL-5 and eosinophil cationic protein were decreased only in the water aerosol group.Our findings confirm the induction of Treg cells and reduction in inflammation by climate therapy. They indicate a synergistic effect of water aerosols resulting in a long-lasting beneficial effect on asthma symptoms, lung function, and airway inflammation. |
| Databáze: | OpenAIRE |
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