Disparities in clinical features and outcomes of peripartum cardiomyopathy in high versus low prevalent regions in Nigeria
| Autor: | Sulaiman A. Balarabe, Idris Y. Mohammed, Isa Oboirien, Karen Sliwa, Vincent Shidali, Kamilu M. Karaye, Simon Stewart, E M Umuerri, Okechukwu S Ogah, Amam Mbakwem, Hadiza Saidu, Sotonye Dodiyi-Manuel, Bashir G. Ahmed, Peripartum Cardiomyopathy in Nigeria (Peace) Registry Investigators, Basil N Okeahialam, Abaram C. Mankwe, Paschal Njoku, Naser A. Ishaq, Veronica Josephs, Jamilu Tukur, Umar G. Adamu, Michael Y. Henein, Taiwo Olunuga |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Peripartum cardiomyopathy PEACE registry Nigeria Outcomes 030204 cardiovascular system & hematology Asymptomatic Regional disparities 03 medical and health sciences Selenium 0302 clinical medicine Selenium deficiency Original Research Articles Internal medicine Statistical significance Post-hoc analysis Peripartum Period Prevalence medicine Humans Diseases of the circulatory (Cardiovascular) system Cardiac and Cardiovascular Systems Original Research Article Prospective Studies 030212 general & internal medicine Kardiologi business.industry medicine.disease RC666-701 Heart failure Female medicine.symptom Cardiomyopathies Cardiology and Cardiovascular Medicine business |
| Zdroj: | ESC Heart Failure, Vol 8, Iss 4, Pp 3257-3267 (2021) ESC Heart Failure |
| Popis: | Aims The prospective, multicentre Peripartum Cardiomyopathy in Nigeria (PEACE) registry originally demonstrated a high prevalence of peripartum cardiomyopathy (PPCM) among patients originating from Kano, North‐West Nigeria. In a post hoc analysis, we sought to determine if this phenomenon was characterized by a differential case profile and outcome among PPCM cases originating elsewhere. Methods and results Overall, 199 (81.6%) of a total 244 PPCM patients were recruited from three sites in Kano, compared with 45 patients (18.4%) from 11 widely dispersed centres across Nigeria. Presence and extent of ventricular myocardial remodelling during follow‐up, relative to baseline status, were assessed by echocardiography. During median 17 months follow‐up, Kano patients demonstrated significantly better myocardial reverse remodelling than patients from other sites. Overall, 50.6% of patients from Kano versus 28.6% from other regions were asymptomatic (P = 0.029) at study completion, with an accompanying difference in all‐cause mortality (17.6% vs. 22.2% respectively, P = 0.523) not reaching statistical significance. Alternatively, 135/191 (84.9%) of Kano patients had selenium deficiency ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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