Ciliary Rootlet Coiled-Coil 2 (crocc2) Is Associated with Evolutionary Divergence and Plasticity of Cichlid Jaw Shape
| Autor: | Emily R. Tetrault, Mary Packard, R. Craig Albertson, Dina Navon, Michelle C Gilbert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Male Genetic Speciation Plasticity AcademicSubjects/SCI01180 craniofacial 010603 evolutionary biology 01 natural sciences phenotypic plasticity 03 medical and health sciences Cichlid Adaptive radiation Genetics Ciliary rootlet Animals eco-devo Molecular Biology Zebrafish Ecology Evolution Behavior and Systematics Discoveries 030304 developmental biology 0303 health sciences Phenotypic plasticity biology Cilium AcademicSubjects/SCI01130 cilia Cichlids biology.organism_classification Adaptation Physiological Cytoskeletal Proteins Jaw Evolutionary biology Developmental plasticity mechanosensing Female human activities |
| Zdroj: | Molecular Biology and Evolution |
| ISSN: | 1537-1719 0737-4038 |
| Popis: | Cichlid fishes exhibit rapid, extensive, and replicative adaptive radiation in feeding morphology. Plasticity of the cichlid jaw has also been well documented, and this combination of iterative evolution and developmental plasticity has led to the proposition that the cichlid feeding apparatus represents a morphological “flexible stem.” Under this scenario, the fixation of environmentally sensitive genetic variation drives evolutionary divergence along a phenotypic axis established by the initial plastic response. Thus, if plasticity is predictable then so too should be the evolutionary response. We set out to explore these ideas at the molecular level by identifying genes that underlie both the evolution and plasticity of the cichlid jaw. As a first step, we fine-mapped an environment-specific quantitative trait loci for lower jaw shape in cichlids, and identified a nonsynonymous mutation in the ciliary rootlet coiled-coil 2 (crocc2), which encodes a major structural component of the primary cilium. Given that primary cilia play key roles in skeletal mechanosensing, we reasoned that this gene may confer its effects by regulating the sensitivity of bone to respond to mechanical input. Using both cichlids and zebrafish, we confirmed this prediction through a series of experiments targeting multiple levels of biological organization. Taken together, our results implicate crocc2 as a novel mediator of bone formation, plasticity, and evolution. |
| Databáze: | OpenAIRE |
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