Frontotemporal Dementia: Correlations Between Psychiatric Symptoms and Pathology
| Autor: | John C. van Swieten, Marta Scarioni, Yannick Timar, Priya Gami-Patel, Yolande A.L. Pijnenburg, Anke A. Dijkstra, Daniela Galimberti, J. J. M. Hoozemans, Elio Scarpini, Annemieke J. M. Rozemuller, Annemiek Dols, Harro Seelaar |
|---|---|
| Přispěvatelé: | Academic Medical Center, Neurology, Amsterdam Neuroscience - Neurodegeneration, Pathology, Psychiatry, APH - Mental Health, Netherlands Institute for Neuroscience (NIN) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Hallucinations Disease Delusions Cohort Studies Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Alzheimer Disease C9orf72 mental disorders medicine Humans Pathological Research Articles Aged Aged 80 and over business.industry Brain nutritional and metabolic diseases Frontotemporal lobar degeneration Middle Aged medicine.disease nervous system diseases DNA-Binding Proteins 030104 developmental biology Neurology Frontotemporal Dementia Compulsive behavior Cohort RNA-Binding Protein FUS Female Autopsy Neurology (clinical) Frontotemporal Lobar Degeneration medicine.symptom business 030217 neurology & neurosurgery Research Article Frontotemporal dementia Cohort study |
| Zdroj: | Annals of neurology, 87(6), 950-961. John Wiley and Sons Inc. Scarioni, M, Gami-Patel, P, Timar, Y, Seelaar, H, van Swieten, J C, Rozemuller, A J M, Dols, A, Scarpini, E, Galimberti, D, Hoozemans, J J M, Pijnenburg, Y A L, Dijkstra, A A & Netherlands Brain Bank 2020, ' Frontotemporal Dementia : Correlations Between Psychiatric Symptoms and Pathology ', Annals of Neurology, vol. 87, no. 6, pp. 950-961 . https://doi.org/10.1002/ana.25739 Annals of Neurology, 87(6), 950-961. John Wiley & Sons Inc. Annals of Neurology, 87(6), 950-961. John Wiley and Sons Inc. Annals of Neurology, 87, 950-961. John Wiley and Sons Inc. Annals of Neurology |
| ISSN: | 0364-5134 |
| DOI: | 10.1002/ana.25739 |
| Popis: | Objective: The pathology of frontotemporal dementia, termed frontotemporal lobar degeneration (FTLD), is characterized by distinct molecular classes of aggregated proteins, the most common being TAR DNA-binding protein-43 (TDP-43), tau, and fused in sarcoma (FUS). With a few exceptions, it is currently not possible to predict the underlying pathology based on the clinical syndrome. In this study, we set out to investigate the relationship between pathological and clinical presentation at single symptom level, including neuropsychiatric features. Methods: The presence or absence of symptoms from the current clinical guidelines, together with neuropsychiatric features, such as hallucinations and delusions, were scored and compared across pathological groups in a cohort of 150 brain donors. Results: Our cohort consisted of 68.6% FTLD donors (35.3% TDP-43, 28% tau, and 5.3% FUS) and 31.3% non-FTLD donors with a clinical diagnosis of frontotemporal dementia and a different pathological substrate, such as Alzheimer's disease (23%). The presence of hyperorality points to FTLD rather than non-FTLD pathology (p < 0.001). Within the FTLD group, hallucinations in the initial years of the disease were related to TDP-43 pathology (p = 0.02), including but not limited to chromosome 9 open reading frame 72 (C9orf72) repeat expansion carriers. The presence of perseverative or compulsive behavior was more common in the TDP-B and TDP-C histotypes (p = 0.002). Interpretation: Our findings indicate that neuropsychiatric features are common in FTLD and form an important indicator of underlying pathology. In order to allow better inclusion of patients in targeted molecular trials, the routine evaluation of patients with frontotemporal dementia should include the presence and nature of neuropsychiatric symptoms. ANN NEUROL 2020;87:950–961. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text