Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy: A prospective randomized, multicenter study
| Autor: | Sung Ae Jung, Byeong Ik Jang, Bong Min Ko, Jai Hyun Choi, Sun-Joo Kim, Jeong Sik Byeon, Won Ho Kim, Il Kwun Chung, Jin Oh Kim, Suk-Kyun Yang, Dong Soo Han, Hwang Choi, Jae Suk Song, Hyo Jong Kim, Yoon Tae Jeen, Hyun Soo Kim, Dong Il Park, Suck Ho Lee |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Colon medicine.medical_treatment Colonic Polyps Colonoscopy Postoperative Hemorrhage Sodium Chloride Injections Intestinal mucosa Colon surgery medicine Humans Vasoconstrictor Agents Colonoscopic Polypectomy Prospective Studies Intestinal Mucosa Prospective cohort study Saline Aged medicine.diagnostic_test business.industry Gastroenterology General Medicine Middle Aged digestive system diseases Polypectomy Surgery Logistic Models Large Colon Female business Rapid Communication |
| Zdroj: | World Journal of Gastroenterology. 13:2973 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v13.i21.2973 |
| Popis: | To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy.A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (10 mm in diameter) were randomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method, and early (12 h) and late bleeding complications (12 h-30 d) were observed.A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall, bleeding complications occurred in 7.6% (37/486) of the patients, including 4.9% (12/244) in the epinephrine group, and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients, respectively, including 4.5% (11/244), 0.4% (1/244) in the epinephrine group, and 8.7% (21/242), 1.7% (4/242) in the saline group. No significant differences in the rates of overall, early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB.The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. |
| Databáze: | OpenAIRE |
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