Preoperative PET/CT in early-stage breast cancer
| Autor: | V.T. Wielenga, Andreas Kjaer, Tina Binderup, U.B. Tange, Anne Kiil Berthelsen, D. Teilum, Martin Andersson, M. Bernsdorf, Annika Loft, Niels Kroman, Jesper Graff |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Breast surgery medicine.medical_treatment Breast Neoplasms Multimodal Imaging Sensitivity and Specificity Diagnosis Differential Breast cancer Fluorodeoxyglucose F18 Preoperative Care medicine Mammography Humans Prospective Studies Stage (cooking) Aged Neoplasm Staging PET-CT medicine.diagnostic_test business.industry Carcinoma Ductal Breast Cancer Hematology Middle Aged medicine.disease Primary tumor Carcinoma Lobular Oncology Positron emission tomography Lymphatic Metastasis Positron-Emission Tomography Female Radiology Radiopharmaceuticals business Tomography X-Ray Computed |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 23(9) |
| ISSN: | 1569-8041 |
| Popis: | Background The aim of this study was to assess the diagnostic and therapeutic impact of preoperative positron emission tomography and computed tomography (PET/CT) in the initial staging of patients with early-stage breast cancer. Patients and methods A total of 103 consecutive patients with newly diagnosed operable breast cancer with tumors ≥2 cm were independently examined preoperatively with conventional assessment (mammography, breast/axillary ultrasound, chest X-ray and blood samples) and PET/CT with no prior knowledge of the other. Results PET/CT identified a primary tumor in all but three patients (97%). PET/CT solely detected distant metastases (ovary, bones and lung) in 6 patients and new primary cancers (ovary, lung) in another two patients, as well as 12 cases of extra-axillary lymph node involvement. In 15 patients (15%), extra-axillary malignancy was detected by PET/CT only, leading to an upgrade of initial staging in 14% (14/103) and ultimately a modification of planned treatment in 8% (8/103) of patients. Conclusions PET/CT is a valuable tool to provide information on extra-axillary lymph node involvement, distant metastases and other occult primary cancers. Preoperative 18F-fluorodeoxyglucose–PET/CT has a substantial impact on initial staging and on clinical management in patients with early-stage breast cancer with tumors ≥2 cm. |
| Databáze: | OpenAIRE |
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