Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
| Autor: | Ji Hee Ha, Rohini Gomathinayagam, Ciro Isidoro, Danny N. Dhanasekaran, Muralidharan Jayaraman, Yong Sang Song |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nigella sativa Cancer Review Biology medicine.disease Chemoprevention Metastasis 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Antineoplastic agent chemistry Neoplasms 030220 oncology & carcinogenesis Cancer cell Cancer research Molecular targets medicine Thymoquinone Signal transduction |
| Zdroj: | Journal of Cancer Prevention |
| ISSN: | 2288-3657 2288-3649 |
| DOI: | 10.15430/jcp.2020.25.3.136 |
| Popis: | Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis. |
| Databáze: | OpenAIRE |
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