Subcutaneous administration of triamcinolone as part of the management of feline eosinophilic keratoconjunctivitis
| Autor: | Lionel Sebbag, Brian C. Leonard, Sara M Thomasy, Danica R. Lucyshyn, Kathryn L. Good, Kelly E. Knickelbein, Ann R. Strom, Steven R. Hollingsworth, Maggie W. Chang, David J. Maggs, K. Tomo Wiggans |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Triamcinolone acetonide 040301 veterinary sciences corneal cytology Keratoconjunctivitis Cat Diseases Triamcinolone Acetonide Corneal Diseases corticosteroids Keratitis 0403 veterinary science antiviral drugs 03 medical and health sciences 0302 clinical medicine Animals Medicine Veterinary Sciences Eosinophilic keratoconjunctivitis Small Animals Retrospective Studies business.industry Evaluation of treatments and therapeutic interventions 04 agricultural and veterinary sciences medicine.disease Dermatology Regimen 6.1 Pharmaceuticals Case-Control Studies Cats 030221 ophthalmology & optometry hypersensitivity business medicine.drug |
| Zdroj: | Journal of feline medicine and surgery, vol 23, iss 6 |
| ISSN: | 1532-2750 1098-612X |
| DOI: | 10.1177/1098612x20968660 |
| Popis: | Objectives The aim of this retrospective case-control study was to report the efficacy of subcutaneous triamcinolone as part of a regimen for feline eosinophilic keratoconjunctivitis (FEK). Methods Records and clinical photographs were reviewed and lesions semiquantitatively graded for cats with cytologically confirmed FEK. Clinical data were compared between a study population of nine cats (11 eyes) treated with, and a reference population of seven cats (eight eyes) treated without, a median of 0.11 mg/kg (range 0.10–0.20 mg/kg) of triamcinolone acetonide subcutaneously. Results Breed, sex, age and prevalence of corneal ulceration at presentation; corneal disease severity before and at the initiation of immunomodulation; and duration of antiviral treatment before immunomodulation did not differ significantly between populations ( P ⩾0.059). Corneal plaques resolved in five cats each from the study and reference populations ( P = 0.366). Median (range) time from immunomodulation to corneal plaque resolution did not significantly differ ( P = 0.246) between the study (median 14 days; range 8–38 days) and reference (median 28 days, range 14–46 days) populations. No adverse reactions were attributed to triamcinolone administration, and all corneal ulcers in the study population re-epithelialized within 14 days (range 8–38 days) following triamcinolone injection. Time to corneal ulcer re-epithelialization following triamcinolone injection varied minimally in those receiving antivirals prior to (8 or 30 days until re-epithelialization), simultaneously with (38 days) or after (14 or 24 days) triamcinolone. Conclusions and relevance In otherwise healthy cats with FEK, subcutaneous administration of triamcinolone appears to be well tolerated and as efficacious as conventional topical immunomodulatory therapies. It may be especially useful in ulcerated eyes where topical immunomodulation is contraindicated. |
| Databáze: | OpenAIRE |
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