Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review
| Autor: | Zarkavelis, George, Kollas, Aristomenes, Kampletsas, E. O., Vasiliou, V., Kaltsonoudis, E., Drosos, Alexandros A., Khaled, H., Pavlidis, Nicholas |
|---|---|
| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961], Drosos, Alexandros A. [0000-0002-2232-0326], Zarkavelis, George [0000-0001-5961-2237] |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Anti-nuclear antibody Arthralgias Review Subacute cutaneous lupus erythematosus 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Breast cancer Systemic lupus erythematosus medicine Aromatase Rheumatoid arthritis General lcsh:Science (General) skin and connective tissue diseases ComputingMethodologies_COMPUTERGRAPHICS lcsh:R5-920 Multidisciplinary biology business.industry Letrozole Antiestrogen medicine.disease Dermatology Aromatase inhibitors 030220 oncology & carcinogenesis Immunology biology.protein lcsh:Medicine (General) business lcsh:Q1-390 Anti-SSA/Ro autoantibodies medicine.drug |
| Zdroj: | Journal of Advanced Research Journal of Advanced Research, Vol 7, Iss 5, Pp 719-726 (2016) |
| Popis: | Graphical abstract Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced. The role of chemotherapeutic agents in causing SCLE has been investigated with the taxanes being the most common anticancer agents. However, recent data emerging point toward antiestrogen therapies as a causative factor not only for SCLE but also for a variety of autoimmune disorders. This is a report of a case of a 42 year old woman who developed clinical manifestations of SCLE after letrozole treatment in whom remission of the cutaneous manifestations was noticed upon discontinuation of the drug. In addition, an extensive review of the English literature has been performed regarding the association of antiestrogen therapy with autoimmune disorders. In conclusion, Oncologists should be aware of the potential development of autoimmune reactions in breast cancer patients treated with aromatase inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|