Cytokines and Soluble HLA-G Levels in the Acute and Recovery Phases of Arbovirus-Infected Brazilian Patients Exhibiting Neurological Complications
| Autor: | Marli Tenório Cordeiro, Ibrahim Sadissou, Norma Lucena-Silva, Renata Santos Almeida, Maria Lucia Brito Ferreira, Eduardo Antônio Donadi, Paulin Sonon, Rafael F. O. França, George Tadeu Nunes Diniz, Maria de Fátima Pessoa Militão-Albuquerque |
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| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Male 0301 basic medicine Eotaxin Chemokine Arbovirus Infections 030231 tropical medicine Immunology medicine.disease_cause Arbovirus Dengue fever Chikungunya (CHIKV) Zika (ZIKV) 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid medicine Humans Immunology and Allergy Chikungunya Dengue (DENV) Original Research HLA-G Antigens biology Zika Virus Infection business.industry Recovery of Function Zika Virus Middle Aged medicine.disease 030104 developmental biology Solubility Neurological Complications Host-Pathogen Interactions biology.protein Cytokines Female Tumor necrosis factor alpha Nervous System Diseases Chemokines lcsh:RC581-607 business Biomarkers Brazil Acute-Phase Proteins |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Severe neurological complications following arbovirus infections have been a major concern in seasonal outbreaks, as reported in the Northeast region of Brazil, where the same mosquito transmitted Zika (ZIKV), Dengue (DENV), and Chikungunya (CHIKV) viruses. In this study, we evaluated the levels of 36 soluble markers, including cytokines, chemokines, growth factors, and soluble HLA-G (Luminex and ELISA) in: i) serum and cerebrospinal fluid (CSF), during the acute phase and two years after the infection (recovery phase, only serum), ii) the relationship among all soluble molecules in serum and CSF, and iii) serum of infected patients without neurological complications, during the acute infection. Ten markers (sHLA-G, IL-10, IL-22, IL-8, MIP-1α, MIP-1β, MCP-1, HGF, VEGF, and IL-1RA) exhibited differential levels between the acute and recovery phases, with pronounced increases in MIP-1α (PPP= 0.0001), and VEGF (P |
| Databáze: | OpenAIRE |
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