Recent Advancements in the Assessment of Renal Transplant Dysfunction with an Emphasis on Microarray Molecular Diagnostics
| Autor: | Jenefer DeKoning, Zahra Kashi, Meagan Barner, Phillip Halloran |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Microarray Clinical Biochemistry 030232 urology & nephrology Transplants 030230 surgery Diagnostic system 03 medical and health sciences 0302 clinical medicine Biopsy medicine Renal transplant rejection Humans Hla antibodies Medical diagnosis medicine.diagnostic_test business.industry Gene Expression Profiling Biochemistry (medical) Molecular diagnostics Kidney Transplantation Molecular Diagnostic Techniques Renal transplant Radiology business |
| Zdroj: | Clinics in laboratory medicine. 38(4) |
| ISSN: | 1557-9832 |
| Popis: | Conventional assessment of renal transplant rejection and injury through use of histology, C4d staining, and HLA antibody testing, has been the standard approach to transplant management. By many measures, these methods of conventional assessment may be considered flawed, particularly with the subjective nature of histologic diagnoses. The Alberta Transplant Applied Genomics Center has developed the Molecular Microscope diagnostic system, which uses microarrays to measure gene expression. These data are analyzed using classifiers (weighted equations) that compare the tested biopsy to a proprietary reference set of biopsies to provide objective measures of the status of the renal transplant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|